Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome

Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term (>=37 Weeks) Neonates With Actant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome: An Open Label Randomized Control Trial

The objective of the study is to compare the total duration of respiratory support in term neonates (≥37weeks) with meconium aspiration syndrome, who are provided early(≤2hr) bolus surfactant therapy versus standard care.

Enrolled participants will be randomly assigned to one of two study groups: 1. early(≤2hr) bolus surfactant replacement therapy or 2. standard care

Intervention group: The neonates enrolled in this group will receive early bolus surfactant replacement therapy within 2hr of life.

Control group: The neonates enrolled in this group will receive standard care according to standard unit protocol

Inclusion Criteria:

• Gestation age ≥ 37 week
• Cephalic presentation
• Singleton pregnancy
• Age < 2 hours
• Baby delivered through meconium stained amniotic fluid
• Presence of respiratory distress (DOWNE's score ≥4)

Exclusion Criteria:

• Major congenital malformation
• Antenatal diagnosed CHD
• Hydrops fetalis
• Air leaks before enrolment