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Age-related hearing loss (ARHL), like neurodegenerative diseases, appears insidiously with age. As major public health issues, they are nonetheless under-diagnosed because the presence of one can hinder the objectification of the other.
The CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| perception disorder in noise in patients weakened by cognitive disorders. | Experimental | The CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VRB test | Diagnostic Test | V1 (inclusion) : VRB test for detecting speech comprehension disorders in noise. V2 (3 months) : all patients ( independent of the result of the VRB test) will be invited to attend a hearing test within 3 months in order to confirm the diagnosis of deafness by means of a tone audiometry and an ENT medical consultation. |
| Measure | Description | Time Frame |
|---|---|---|
| Ability of the VRB test to detect deafness in patients over 50 with mild to moderate cognitive impairment. | Area under the ROC (receiver operating characteristic) curve of the VRB test for hearing loss screening. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the diagnostic values of the VRB threshold associated with a disorder of speech comprehension in noise defined in the general population to screen for deafness in patients over 50 years of age with mild to moderate cognitive impairment. | Sensitivity, specificity, negative and positive predictive values of the pathological threshold defined in the general population (>3 BSR ) for hearing loss screening (as defined in the primary endpoint) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pascaline Cassagnaud | Contact | 03.20.44 60 21 | Pascaline.CASSAGNAUD@chu-lille.fr | |
| Juliette Bochu | Contact | 0320444145 | juliette.bochu@chu-lille.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Roger Salengro | Recruiting | Lille | 59037 | France |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D003638 | Deafness |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D034381 | Hearing Loss |
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|
| 3 months or 12 months |
| correlation between the hearing loss and the auditory discomfort (complaint) expressed by the patient and that observed by the caregiver | Hearing loss is defined by the VRB test score. The auditory complaint expressed by the patient is defined by the score on the HHIE-S questionnaire completed by the patient himself; the auditory complaint noted by the entourage is defined by the score on the adapted HHIE-S questionnaire completed by the caregiver present at the consultation at M0. | 3 months or 12 months |
| Frequency of patients with hearing aids at 12 months. | Frequency of patients with hearing aids at 12 months from inclusion | 3 months or 12 months |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | Variation in scores between M0 and M12 on HAD neuropsychological and speech therapy test. | 3 months or 12 months |
| To assess the correlation between an objective cortical marker of selective attention (long latency evoked potentials: P300 wave amplitude; patients' ability to discriminate sounds in silence), and subjects' performance in tone audiometry in silence | Amplitude and latency of the P300 wave; Tone audiometry score in silence. | 3 months or 12 months |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | Variation in scores between M0 and M12 on WHOQOL-BREF neuropsychological test | 3 months or 12 months |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | Variation in scores between M0 and M12 on QFS functional scale | 3 months or 12 months |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | Variation in scores between M0 and M12 on LARS neuropsychological test. | 3 months or 12 months |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | Variation in scores between M0 and M12 on EQ-5D-3L neuropsychological test. | 3 months or 12 months |
| D006311 |
| Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |