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This study will test the feasibility and effectiveness of an innovative model of care for cognitively impaired patients with heart failure. This program aims to improve cognition, reduce dementia risk and cardiovascular events, and will be supported by innovative digital technology for wide scale rollout and implementation. Findings from this research will transform the way healthcare is delivered to cognitively impaired patients with heart disease who have a very high risk of developing dementia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Usual care | No Intervention | Usual care patients will continue with the hospital follow-up plan and routine preventive care after hospital discharge. | |
| Intervention | Experimental | Intervention patients will receive a disease management program in addition to the usual care. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Disease management program | Other | The components of our DMP include:
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in MOCA score | Greater Montreal Cognitive Assessment (MOCA) score (ranging 0-30) is better | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardiac function | Cardiac function will be measured by echocardiography. Left ventricular global longitudinal strain will be the primary measure of cardiac function. | 12 months |
| Change in 6-minute walk distance |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Quan Huynh | Contact | 610385321833 | quan.huynh@baker.edu.au |
| Name | Affiliation | Role |
|---|---|---|
| Thomas H Marwick, MBBS PhD MPH | Baker Heart and Diabetes Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Menzies Institute for Medical Research | Recruiting | Hobart | Tasmania | 7000 | Australia |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| D018487 | Ventricular Dysfunction, Left |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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|
Functional capacity will be based on 6-minute walk test
| 12 and 24 months |
| Change in quality of life | Quality of life specific to heart failure symptoms will be measured using a disease-specific quality of life questionnaire: Kansas City Cardiomyopathy Questionnaire | 12 and 24 months |
| Change in MOCA score | Greater Montreal Cognitive Assessment (MOCA) score (ranging 0-30) is better | 24 months |
| Change in brain volume via MRI measurement | 24 months |
| Change in hand grip strength | 12 and 24 months |
| Change in heart failure classification | Based on New York Heart Association classification | 12 and 24 months |
| D001523 |
| Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D018754 | Ventricular Dysfunction |