The current study aims to evaluate the efficacy and safety of pBFS-guided cTBS combined with iTBS for the rehabilitation of language functions in patients with post-ischemic stroke aphasia.

Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized cTBS combined with iTBS intervention in post-stroke aphasic patients.

Subjects will be randomly assigned to the following two groups: active TBS（cTBS+iTBS）group, or a sham TBS（sham cTBS+sham iTBS）group. The allocation ratio will be 1:1. The stimulation protocol consisted of a 3-week treatment, with five consecutive days each week (totally 15 day-treatment) .The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.

Inclusion Criteria:

1. The patient's age ranges from 35 to 75 years old (including 35 and 75 years old);
2. Meet the diagnostic criteria for acute ischemic stroke (diagnosed according to the "Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke" written by the American Heart Association/American Stroke Association in 2019 and the "Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2018" compiled by the Neurology Branch of the Chinese Medical Association in 2018), with lesions in the left hemisphere, and a duration of ≥15 days and ≤3 months;
3. Diagnosed as aphasia patient according to the Chinese version of Western Aphasia Battery (WAB), with a WAB-aphasia quotient of less than 93.8 points;
4. First onset of stroke;
5. Normal functioning language abilities before the stroke, with Mandarin as their native language and an educational level higher than primary school；
6. Understand the trial and signed the informed consent form.

Exclusion Criteria:

1. Combined severe dysarthria (NIHSS item 10 score ≥2 points);
2. Aphasia caused by bilateral hemisphere stroke, brain tumor, traumatic brain injury, Parkinson's disease, motor neuron disease, or other diseases；
3. Patients with implanted electronic devices such as cardiac pacemakers, cochlear implants, or other metal foreign bodies, or those with MRI contraindications such as claustrophobia or TMS treatment contraindications;
4. History of epilepsy;
5. Patient with concomitant severe systemic diseases affecting the heart, lungs, liver, kidneys, etc., and uncontrolled by conventional medication, as detected and confirmed through laboratory testing and examination;
6. Patients with consciousness disorders (NIHSS 1(a) score ≥1);
7. Patients with malignant hypertension;
8. Patients with severe organic diseases, such as malignant tumors, with an expected survival time of less than 1 year;
9. Patients with severe hearing, visual, cognitive impairment or inability to cooperate with the trial;
10. Patients with severe depression, anxiety, or diagnosed with other mental illnesses that prevent them from completing the trial;
11. Patients who have received other neuroregulatory treatments such as TMS, transcranial electric stimulation, etc. in the 3 months prior to enrollment;
12. Patients with a history of alcoholism, drug abuse, or other substance abuse;
13. Patients with other abnormal findings that the researchers judge are not suitable for participation in this trial;
14. Patients who are unable to complete follow-up due to geographical or other reasons;
15. Women of childbearing age who are currently pregnant, breastfeeding, or planning or may become pregnant during the trial;
16. Patients who are currently participating in other clinical trials.