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This retrospective studed included patients referred to our institution between December 2013 and december 2021 for septoplasty or septorhinoplasty. All patients underwent pre operatory paranasal sinus CT scan and olfactory test. Olfacory cleft stenosis will be quoted as none (less than 1/3 contact between nasal septum and ethmoïd turbinates), partial (1/3-2/3 contact between nasal septum and turbinates) or total (more than 2/3 contact between nasal septum and turbinates), as well as Olfactory Cleft obstruction as none (opacification less than 1/3 of olfactory cleft), partial (1/3-2/3 opacification) or complete (more than 2/3 opacification).
In this retrospective study, We will include every patients over 18 years old who had a septoplasty or septorhinoplasty between December 2013 and December 2021 and who underwent paranasal CT scan and olfactory test (sniffin stick test).
The patients will be find thanks to social security code GAMA007 for septoplastie, GAMA 004, 010 for septorhinoplasty and olfactometry GJQP001.
The patients with mucosa pathology on CT scan or with record of chronic respiratory rhinitis, septum perforation or a pathology that can alter the olfaction on the consultation report will be excluded.
Olfactory measurements were performed before surgery using the threshold and identification subtests of Sniffin Stick Test. Olfactory status will be classified by taking into account the normative data provided by Hummel et al and the real identification score. The patients will be classified as normosmic if the threshold and the identification score is superior the tenth percentile. If not, they will be classified as anosmic if both score are 0 and hyposmic otherwise.
2 experienced radiologists will perform the measures on paranasal sinus CT. They will be blinded to olfactory results.
The olfactory cleft boundaries were determined in the coronal plane : Anterior boundary was defined by the anterior attachment of the middle turbinate; the posterior boundary corresponding to the anterior face of the sphenoid sinus; the lateral boundaries were defined as the attachment of the middle and/or superior turbinate laterally and the nasal septum medially. Olfactory clefts were divided into an anterior and a posterior compartment, defined as "middle olfactory recess" and "superior olfactory recess", laterally bounded by the middle and the superior turbinate lamella, respectively.
Each olfactory recess width, global olfactory Cleft width and cribriform plate width will be measured in the coronal plane, at the level of the cribriform plate and 5mm underneath at 5 different sites :
Olfacory cleft stenosis will be quoted as none (less than 1/3 contact between nasal septum and ethmoïd turbinates), partial (1/3-2/3 contact between nasal septum and turbinates) or total (more than 2/3 contact between nasal septum and turbinates), A global olfactory cleft status will be obtained : no significant or partial stenosis in any compartment, total stenosis in case of complete stenosis in every compartment and intermediate stenosis in any other situation.
Olfactory Cleft obstruction will be classified as none (opacification less than 1/3 of olfactory cleft), partial (1/3-2/3 opacification) or complete (more than 2/3 opacification).
Olfactory cleft lateral boundaries will be evaluated for the presence of a lamellar pneumatization (superior, middle or lamellar concha bullosa).
Olfactory groove depth was classified according to the Keros classification in regard of the middle and superior olfactory recess.
as well as Olfactory Cleft obstruction as none (opacification less than 1/3 of olfactory cleft), partial (1/3-2/3 opacification) or complete (more than 2/3 opacification).
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| Measure | Description | Time Frame |
|---|---|---|
| Olfactory cleft stenosis or obstruction | Measures will classify as none, partial or total stenosis or obstruction | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of olfactory cleft stenosis or obstruction | Are patients with stenosis or obstruction hypsomic or anosmic | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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- Patients over 18 years old who underwent paranasal sinus CT and olfactory test before septoplasty or septorhinoplasty without respiratory mucosa pathology Sex, mean age Olfactory test threshold and identification using sniffin stick test. Classification normosmic or hyposmic using Hummel table.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jankowski Roger | Recruiting | Nancy | 54000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12200342 | Background | Jafek BW, Murrow B, Michaels R, Restrepo D, Linschoten M. Biopsies of human olfactory epithelium. Chem Senses. 2002 Sep;27(7):623-8. doi: 10.1093/chemse/27.7.623. | |
| 23932763 | Background | Leboucq N, Menjot de Champfleur N, Menjot de Champfleur S, Bonafe A. The olfactory system. Diagn Interv Imaging. 2013 Oct;94(10):985-91. doi: 10.1016/j.diii.2013.06.006. Epub 2013 Aug 7. |
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The initial database of patients with olfactory measure and septoplasty or septorhinoplasty can be used for other research as well the one with the patients included (without mucosa pathology)
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| Centre Hospitalier Régional Universitaire - Service ORL | Recruiting | Nancy | France |
|
| 14990917 | Background | Biacabe B, Faulcon P, Amanou L, Bonfils P. Olfactory cleft disease: an analysis of 13 cases. Otolaryngol Head Neck Surg. 2004 Feb;130(2):202-8. doi: 10.1016/j.otohns.2003.09.002. |
| 29074286 | Background | Jankowski R, Rumeau C, Gallet P, Nguyen DT, Russel A, Toussaint B. Endoscopic surgery of the olfactory cleft. Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Apr;135(2):137-141. doi: 10.1016/j.anorl.2017.09.005. Epub 2017 Oct 23. |
| 29934261 | Background | Jankowski R, Nguyen DT, Gallet P, Rumeau C. Olfactory cleft dilatation. Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Dec;135(6):437-441. doi: 10.1016/j.anorl.2018.05.008. Epub 2018 Jun 20. |
| 32292482 | Background | Jiang RS, Liang KL. The Effect of Endoscopic Olfactory Cleft Opening on Obstructed Olfactory Cleft Disease. Int J Otolaryngol. 2020 Mar 27;2020:8073726. doi: 10.1155/2020/8073726. eCollection 2020. |
| 26163252 | Background | Kuperan AB, Lieberman SM, Jourdy DN, Al-Bar MH, Goldstein BJ, Casiano RR. The effect of endoscopic olfactory cleft polyp removal on olfaction. Am J Rhinol Allergy. 2015 Jul-Aug;29(4):309-13. doi: 10.2500/ajra.2015.29.4191. |
| 25752823 | Background | Nguyen DT, Bey A, Arous F, Nguyen-Thi PL, Felix-Ravelo M, Jankowski R. Can surgeons predict the olfactory outcomes after endoscopic surgery for nasal polyposis? Laryngoscope. 2015 Jul;125(7):1535-40. doi: 10.1002/lary.25223. Epub 2015 Mar 5. |
| 23883814 | Background | Nguyen DT, Gauchotte G, Nguyen-Thi PL, Jankowski R. Does surgery of the olfactory clefts modify the sense of smell? Am J Rhinol Allergy. 2013 Jul-Aug;27(4):317-21. doi: 10.2500/ajra.2013.27.3907. |
| 19841336 | Background | Chang H, Lee HJ, Mo JH, Lee CH, Kim JW. Clinical implication of the olfactory cleft in patients with chronic rhinosinusitis and olfactory loss. Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):988-92. doi: 10.1001/archoto.2009.140. |
| 28124650 | Background | Kohli P, Schlosser RJ, Storck K, Soler ZM. Olfactory cleft computed tomography analysis and olfaction in chronic rhinosinusitis. Am J Rhinol Allergy. 2016 Nov 1;30(6):402-406. doi: 10.2500/ajra.2016.30.4365. |
| 31603563 | Background | Loftus C, Schlosser RJ, Smith TL, Alt JA, Ramakrishnan VR, Mattos JL, Mappus E, Storck K, Yoo F, Soler ZM. Olfactory cleft and sinus opacification differentially impact olfaction in chronic rhinosinusitis. Laryngoscope. 2020 Oct;130(10):2311-2318. doi: 10.1002/lary.28332. Epub 2019 Oct 11. |
| 26010298 | Background | Soler ZM, Pallanch JF, Sansoni ER, Jones CS, Lawrence LA, Schlosser RJ, Mace JC, Smith TL. Volumetric computed tomography analysis of the olfactory cleft in patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Sep;5(9):846-54. doi: 10.1002/alr.21552. Epub 2015 May 26. |
| 32917809 | Background | Eliezer M, Hamel AL, Houdart E, Herman P, Housset J, Jourdaine C, Eloit C, Verillaud B, Hautefort C. Loss of smell in patients with COVID-19: MRI data reveal a transient edema of the olfactory clefts. Neurology. 2020 Dec 8;95(23):e3145-e3152. doi: 10.1212/WNL.0000000000010806. Epub 2020 Sep 11. |
| 33045908 | Background | Altundag A, Yildirim D, Tekcan Sanli DE, Cayonu M, Kandemirli SG, Sanli AN, Arici Duz O, Saatci O. Olfactory Cleft Measurements and COVID-19-Related Anosmia. Otolaryngol Head Neck Surg. 2021 Jun;164(6):1337-1344. doi: 10.1177/0194599820965920. Epub 2020 Oct 13. |
| 34569549 | Background | Tekcan Sanli DE, Altundag A, Yildirim D, Kandemirli SG, Sanli AN. Comparison of Olfactory Cleft Width and Volumes in Patients with COVID-19 Anosmia and COVID-19 Cases Without Anosmia. ORL J Otorhinolaryngol Relat Spec. 2022;84(1):1-9. doi: 10.1159/000518672. Epub 2021 Sep 21. |
| 36318894 | Background | Alves de Sousa F, Tarrio J, Sousa Machado A, Costa JR, Pinto C, Nobrega Pinto A, Moreira B, Meireles L. Olfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunction. ORL J Otorhinolaryngol Relat Spec. 2023;85(3):119-127. doi: 10.1159/000527141. Epub 2022 Nov 1. |
| 17216743 | Background | Lima NB, Jankowski R, Georgel T, Grignon B, Guillemin F, Vignaud JM. Respiratory adenomatoid hamartoma must be suspected on CT-scan enlargement of the olfactory clefts. Rhinology. 2006 Dec;44(4):264-9. |
| 33132007 | Background | Kandemirli SG, Altundag A, Yildirim D, Tekcan Sanli DE, Saatci O. Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia. Acad Radiol. 2021 Jan;28(1):28-35. doi: 10.1016/j.acra.2020.10.006. Epub 2020 Oct 19. |
| 29661611 | Background | Jankowski R, Rumeau C, Gallet P, Nguyen DT. Nasal polyposis (or chronic olfactory rhinitis). Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Jun;135(3):191-196. doi: 10.1016/j.anorl.2018.03.004. Epub 2018 Apr 13. |
| 31515050 | Background | Whyte A, Boeddinghaus R. Imaging of adult nasal obstruction. Clin Radiol. 2020 Sep;75(9):688-704. doi: 10.1016/j.crad.2019.07.027. Epub 2019 Sep 9. |
| 17021776 | Background | Hummel T, Kobal G, Gudziol H, Mackay-Sim A. Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol. 2007 Mar;264(3):237-43. doi: 10.1007/s00405-006-0173-0. Epub 2006 Sep 23. |
| 26384780 | Background | Nguyen DT, Rumeau C, Gallet P, Jankowski R. Olfactory exploration: State of the art. Eur Ann Otorhinolaryngol Head Neck Dis. 2016 Apr;133(2):113-8. doi: 10.1016/j.anorl.2015.08.038. Epub 2015 Sep 15. |
| ID | Term |
|---|---|
| D000857 | Olfaction Disorders |
| ID | Term |
|---|---|
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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