Danish Angle Closure Prevention Trial

Danish Angle Closure Prevention Trial

To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.

Prospective, randomised paired-eye design clinical trial comparing peripheral laser iridotomy in one eye with observation in the other over 5-years follow-up.

Inclusion Criteria:

• Primary angle closure suspect: ≥180 degrees (cumulative) irido-trabecular contact on darkroom gonioscopy, IOP<21mmHg, no peripheral anterior synechiae, no glaucomatous optic neuropathy
• Best-corrected visual acuity (BCVA) >0.8 on both eyes
• Caucasian

Exclusion Criteria:

• Pseudophakia
• Previous iridotomy
• Clinically significant cataract with indication for surgery,
• Gaucoma
• Uveitis
• Unstable retinal conditions
• Ocular malignancies
• PEX
• PDS
• Systemic or ocular corticosteroid treatment