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To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.
Prospective, randomised paired-eye design clinical trial comparing peripheral laser iridotomy in one eye with observation in the other over 5-years follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm 1 | Other | One eye iridotomy, contralateral eye no intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iridotomy | Procedure | Peripheral iridotomy (size >200µm) |
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| Measure | Description | Time Frame |
|---|---|---|
| Intraocular pressure | GAT: ≥24mmHg or ≥22mmHg on two separate occasions | 5 year |
| Glaucoma | The presence of glaucomatous optic neuropathy with visual field loss compatible with glaucoma. Glaucomatous optic neuropathy defined as loss of neuroretinal rim (notch or erosion), a vertical cup-to-disc ratio of more than 0.7, nerve fiber layer defect attributable to glaucoma, or both. | 5 year |
| Acute Primary Angle Closure | Presence of at least 2 of the following symptoms: ocular or periocular pain; nausea, vomiting, or both; an antecedent history of intermittent blurring of vision with haloes and IOP of more than 30 mmHg and presence of at least 3 of the following signs: conjunctival injection, corneal epithelial edema, mid-dilated unreactive pupil, glaukomflecken, and shallow anterior chamber; | 5 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Niklas Telinius, PhD, DMSc | Contact | +4530238533 | telinius@me.com |
| Name | Affiliation | Role |
|---|---|---|
| Niklas Telinius | Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aalborg University Hospital | Recruiting | Aalborg | 9000 | Denmark |
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One eye intervention (prophylactic iridotomy), one eye no intervention
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| Aarhus University Hospital | Recruiting | Aarhus | 8240 | Denmark |
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| Rigshospitalet Glostrup | Recruiting | Glostrup Municipality | 2600 | Denmark |
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| Odense University Hospital | Not yet recruiting | Odense | 5000 | Denmark |
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| Sygehus Lillebælt | Recruiting | Vejle | 7100 | Denmark |
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