The distribution of demographic, clinical, radiological, pathological and molecular characteristics of lung cancer at the time of diagnosis, as well as preferential association between elements of those domains, have not been specifically studied in Italy. The aim of the present project is to assess, in a systematic fashion, the demographic, clinical, radiological, pathological and molecular characteristics of advanced lung cancer at the time of diagnosis in a large Italian cohort of consecutive patients referred to two tertiary referral centers.

Inclusion Criteria:

• Age >18 years
• Suspicion of lung cancer based on imaging (CT and/or PET/CT)
• Indication to a biopsy for diagnosis, staging and/or molecular profiling

Exclusion Criteria:

• Inability or unwillingness to provide a written informed consent
• ECOG performance status (>3) which makes a tissue diagnosis unfeasible
• ASA 4 status
• TNM Stage I-III

Consecutive, treatment-naïve, patients with clinical and radiological suspicion of advanced lung cancer referred for the initial diagnosis/staging/molecular profiling.

The investigators will decide how to share the data at the end of the study upon reasonable request to be addressed to the principal investigator.