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Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.
Almonds are energy-dense and rich in beneficial nutrients including B vitamins, vitamin E, mono- and polyunsaturated fatty acids, protein, fiber, minerals and polyphenols. Polyphenols and vitamin E in almonds provide protection to the body in part, through their ability to combat oxidative stress. Clinical studies have demonstrated beneficial effects of almond consumption on diseases such as diabetes and cardiovascular disease.
Almond consumption has been shown to significantly decrease wrinkle severity in two clinical studies conducted with postmenopausal women with Fitzpatrick skin type I and II. Almond intake has also been shown to increase resistance to erythema induced by ultraviolet exposure. The extracellular matrix contains proteins including collagen and elastin, which contributes to the integrity of the skin. Enzymatic and ultraviolet radiation induced degradation and a reduction in synthesis of collagen and elastin contribute to wrinkle formation. Furthermore, the process of menopause decreases the level of estrogen which affects the skin in several ways, including a decrease in skin collagen and hydration, and an increase in wrinkling.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Almonds | Experimental | Consumption of almonds 5 times per week |
|
| Control Snack | Placebo Comparator | Consumption of protein and calorie matched non-nut-based food 5 times per week |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Food: whole almonds | Other | 60 grams or (~2 oz) will be consumed 5 times per week. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Skin collagen and elastin quantification | Assess with biopsy based histological examination | 24 weeks |
| Facial wrinkles | Wrinkle severity score measured by Facial Image Analysis System (BTBP 3D image analysis system). Higher scores indicate worsened wrinkle severity and lower scores represent improvement in wrinkle severity. | 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Pigment intensity score | Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation. | 12 Weeks |
| Pigment intensity score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sarah Adnan | Contact | 9168074299 | sarah@integrativeskinresearch.com |
| Name | Affiliation | Role |
|---|---|---|
| Raja Sivamani, MD MS AP | Integrative Skin Science and Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Integrative Skin Science and Research | Recruiting | Sacramento | California | 95819 | United States |
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| ID | Term |
|---|---|
| D004535 | Ehlers-Danlos Syndrome |
| ID | Term |
|---|---|
| D020141 | Hemostatic Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006474 | Hemorrhagic Disorders |
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| Food: non-nut snack |
| Other |
Protein and calorie matched non-nut-based food will be consumed 5 times per week by mouth |
|
Change in the appearance of facial pigmentation by high resolution photography (BTBP Clarity Pro) and measures intensity of facial pigmentation. Higher scores indicate darker pigmentation.
| 24 Weeks |
| Expression of enzymes that either degrade collagen (MMP1) or inhibit collagen degradation (TIMP1) on skin biopsies | Assess through biopsy based histological examination | 24 Weeks |
| Plasma for potential AGE (advanced glycation end products) analysis | Blood samples will be collected | 12 Weeks |
| Plasma for potential AGE (advanced glycation end products) analysis | Blood samples will be collected | 24 Weeks |
| Facial Wrinkles | Wrinkle severity score measured by Facial Image Analysis System (BTBP 3D image analysis system). Higher scores indicate worsened wrinkle severity and lower scores represent improvement in wrinkle severity. | 12 Weeks |
| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D012868 | Skin Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D003095 | Collagen Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D012871 | Skin Diseases |