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The Sickle Cell Children's Exercise Study (SuCCESs) will explore the feasibility and effects of a moderate intensity strengthening, balance, speed, and agility intervention program in children with sickle cell disease.
Participants will perform the baseline assessment and after six weeks of performing the SuCCESs program the participants will perform a post-intervention assessment. Participants will be asked to attend a total of six physical therapy in-person sessions (1x/week) at the University of Maryland Department of Physical Therapy and Rehabilitation Science and to perform 12 home program sessions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical Therapy Exercise | Experimental | There will be no control group and only one intervention delivered |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SuCCESs | Behavioral | strengthening and endurance exercises |
|
| Measure | Description | Time Frame |
|---|---|---|
| knee extension strength | dynamometry to measure knee extension strength | week 1 and week 7 |
| Rate of Muscle Activation | Electromyography used to measure rate of muscle activation | week 1 and week 7 |
| exercise tolerance | 6-Minute Walk Test used to measure exercise tolerance | week 1 and week 7 |
| locomotor efficiency | oxygen uptake used to measure locomotor efficiency | week 1 and week 7 |
| number of sessions attended | attendance | throughout the entire study week 1, weeks 2-6, six weeks of intervention, and week 7 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science | Baltimore | Maryland | 21201-1082 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34592159 | Background | Marchese V, Rock K, Harpold A, Salazar A, Williams M, Shipper AG. Physical Impairment and Function in Children and Adolescents With Sickle Cell Disease: A Systematic Review. Arch Phys Med Rehabil. 2022 Jun;103(6):1144-1167.e2. doi: 10.1016/j.apmr.2021.08.022. Epub 2021 Sep 27. | |
| 34721067 | Background | Lanza MB, Rock K, Marchese V, Addison O, Gray VL. Hip Abductor and Adductor Rate of Torque Development and Muscle Activation, but Not Muscle Size, Are Associated With Functional Performance. Front Physiol. 2021 Oct 14;12:744153. doi: 10.3389/fphys.2021.744153. eCollection 2021. |
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| ID | Term |
|---|---|
| D000755 | Anemia, Sickle Cell |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
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feasibility study
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One physical therapist will perform the pre- and post-test assessment measures and another pediatric physical therapist will perform the intervention sessions.
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| University of Maryland, Baltimore | Baltimore | Maryland | 21201 | United States |
| 36843306 | Background | Ho S, Rock K, Marchese V. Diaphragm excursion correlates with performance and ventilation on the 6-min walk test in children with sickle cell disease. Pediatr Pulmonol. 2023 Jun;58(6):1665-1673. doi: 10.1002/ppul.26373. Epub 2023 Mar 8. |
| 33563044 | Background | Rock K, Nelson C, Addison O, Marchese V. Assessing the Reliability of Handheld Dynamometry and Ultrasonography to Measure Quadriceps Strength and Muscle Thickness in Children, Adolescents, and Young Adults. Phys Occup Ther Pediatr. 2021;41(5):540-554. doi: 10.1080/01942638.2021.1881200. Epub 2021 Feb 9. |
| D006425 |
| Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |