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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL166306 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours/day) could improve cardiovascular and metabolic health in habitual short sleepers.
Short sleep duration is associated with increased cardiovascular and metabolic risk with consequent increased cardiovascular mortality. Increasing sleep duration mitigates the metabolic impairment, but alternate strategies to reduce cardiometabolic risk in habitual short sleepers are lacking. This is especially important when increasing sleep duration is unsuccessful. Unfortunately, the underlying mechanisms through which shortened sleep contributes to metabolic detriments are not completely understood. This hinders the development of alternate strategies for cardiovascular prevention in short sleepers. However, a widespread factor potentially underlying metabolic dysfunction in short sleepers seems to be circadian misalignment (decreased and delayed melatonin secretion) partly resulting from mistimed eating. Importantly, eating behavior may be targeted to improve metabolism in short sleepers. Specifically, limiting the daily eating period as shown by the many recent interventions of time restricted eating (TRE) may potentiate circadian alignment (melatonin rhythms) and improve metabolism in habitual short sleepers.
The goal of the study is to examine the metabolic and circadian effects of eating duration in habitual short sleepers. The investigators propose a two-group, parallel arm study during which participants will be randomized to either continue with habitual >14h/day (extended) or restricted 8h/day (TRE) eating duration. The overarching hypothesis is that extended eating duration contributes to high blood pressure (BP), insulin resistance (IR), and a decreased and delayed melatonin secretion in habitual short sleepers. Therefore, TRE will reduce BP, IR along with an increased and earlier onset of melatonin secretion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Time restricted eating (TRE) | Experimental | Subjects randomized to this arm will be asked to follow an 8h eating duration/day for 4 weeks. |
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| Habitual eating duration | No Intervention | Subjects randomized to this arm will be asked to continue habitual eating duration of >14h/day for 4 weeks. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Time restricted eating (TRE) | Behavioral | Subjects randomized to this arm will be asked to follow an 8h eating duration/day for 4 weeks. Participants will be asked to continue habitual sleep patterns. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 24h mean arterial blood pressure (MAP) | Change in 24h MAP from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated. | Baseline to 4 weeks |
| Change in insulin resistance | Change in insulin resistance from pre-intervention to end-intervention. Insulin resistance will be determined by standard 3h mixed meal tolerance test and calculated as ratio of incremental area under the curve values for insulin and glucose. Difference between habitual eating period and TRE will be evaluated. | Baseline to 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 24h systolic blood pressure (SBP) | Change in 24h SBP from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated. | Baseline to 4 weeks |
| Change in postprandial glycemic excursion |
| Measure | Description | Time Frame |
|---|---|---|
| Change in clock time for dim light melatonin onset | Change in clock time for dim light melatonin onset from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated. | Baseline to 4 weeks |
| Change in clock time for dim light melatonin offset |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Prachi Singh, PhD | Contact | 225-762-3151 | prachi.singh@pbrc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Prachi Singh, PhD | Pennington Biomedical Research Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Recruiting core Pennington | Recruiting | Baton Rouge | Louisiana | 70808 | United States |
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| ID | Term |
|---|---|
| D012892 | Sleep Deprivation |
| D000093763 | Intermittent Fasting |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
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Change in postprandial glycemic excursion from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated.
| Baseline to 4 weeks |
Change in clock time for dim light melatonin offset from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated. |
| Baseline to 4 weeks |
| Change in melatonin area under the curve (AUC) | Change in AUC from melatonin onset to offset from pre-intervention to end-intervention. Difference between habitual eating period and TRE will be evaluated. | Baseline to 4 weeks |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001523 | Mental Disorders |
| D005215 | Fasting |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |