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The aim of the study will be to evaluate shear stress and blood flow parameters in lower limb arteries during arm cycle ergometer exercise in participants with peripheral artery disease. Twenty patients participants with peripheral artery disease and claudication symptoms will be recruited. Participants will perform 3 experimental sessions in random order. Iarm-cranking (15 sets of two minutes exercise), warm water foot immersion, and control. During the interventions, blood pressure and heart rate will be assessed every 6 minutes. Measurements of arterial diameter, blood flow, anterograde and retrograde shear stress of the femoral artery will be evaluated using a two-dimensional ultrasound device with spectral Doppler.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Arm-cranking exercise | Experimental | Patients will be perform arm-cranking exercise. The exercise will be performed in 15 sets of 2 min of exercise at a moderate intensity (13-15 in Borg scale) |
|
| Heating | Active Comparator | Patients will perform 15 sets of 2 min of immersion of their foot in a warm water (42 degrees) |
|
| Control | No Intervention | Patients will remain seated for 60 min |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arm-cranking exercise | Other | Arm-cranking exercise |
|
| Measure | Description | Time Frame |
|---|---|---|
| Femoral artery diameter [mm] | Measurements will be obtained through duplex ultrasound in accordance with global recommendations. | Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention |
| Femoral artery shear rate [sec.-1] | Measurements will be obtained through duplex ultrasound in accordance with global recommendations. | Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention |
| Femoral artery Blood flow [mL/min] | Measurements will be obtained through duplex ultrasound in accordance with global recommendations. | Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial systolic and diastolic blood pressure [mmHg] | Systolic and diastolic blood pressures will be assessment in the arms with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan) | Before the intervention and at 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, and 29 minutes into the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raphael Dias | University of Nove de Julho | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Nove de Julho | SĆ£o Paulo | 01504-001 | Brazil |
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One year after the study completion
Upon request
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| ID | Term |
|---|---|
| D058729 | Peripheral Arterial Disease |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| D015444 | Exercise |
| D006361 | Heating |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Heating | Other | Immersion of the foot in warm water |
|
| Heart rate [bpm] |
Heart rate assessment with a heart rate monitor (Polar H10, PolarĀ®, Finland) |
| Before and up to 30 minutes into the intervention |
| D002318 |
| Cardiovascular Diseases |
| D016491 | Peripheral Vascular Diseases |
| D001519 | Behavior |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D004780 | Environment, Controlled |
| D004777 | Environment |
| D004778 | Environment and Public Health |