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The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break ([walk]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Break dual task | Experimental | Subjects will remain seated for three hours; however, every 30 minutes the subjects will be instructed to stand and take short walks with low intensity and perform a cognitive task |
|
| Standard break | Active Comparator | Subjects will remain seated for three hours, however, every 30 minutes the subjects will be instructed to stand and take short walks at low intensity for two minutes, |
|
| Control session | No Intervention | Subjects will remain seated for three hours |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Break of sedentary behavior with dual task | Other | Patients will interrupt sedentary behavior performing walking and cognitive activities simultaneously |
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| Measure | Description | Time Frame |
|---|---|---|
| Cerebral blood velocity [centimeters per second] | Mean arterial velocity of middle cerebral artery will be measured using a transcranial doppler | Before and 20 minutes after the intervention for 5 minutes |
| Cognitive function - The Trail Making Tests [seconds] | The Trail Making Tests (A and B) will be used to assess executive function and attention. Part A will determine psychomotor speed and require the participant to draw lines connecting sequentially circled numbers, such as drawing a line from 1 to 2, 2 to 3, and 3 to 4. Part B will consist of circled numbers and letters. Participants will be instructed to draw a line as quickly and as accurately as possible from 1 to A, A to 2, 2 to B, B to 3, and so on, until they complete the task. The time in seconds will be recorded in seconds after the end of each stage. After carrying out the tests, the differences between the completion times for part B - A will be calculated. | Before and 30 minutes after the intervention |
| Cognitive function - Stroop test [seconds] | A computerized version of the Stroop test will be used in this study, using the Testinpacs® program. The tasks will be viewed on a notebook screen approximately 90 cm away from the participant. Answers to a set of tasks will be given as quickly as possible via two buttons. The cognitive portion of the Stroop test will be used as a psychometric test to assess cognition, being related to the executive functions of decision-making and inhibitory control exercised by the prefrontal cortex. The capacity for selective attention and response control will be estimated as the time difference between the third condition and the second condition. Smaller differences will indicate better selective attention and conflict resolution. | Before and 32 minutes after the intervention |
| Cognitive function - verbal fluency [number of animal names reported] | The task will consist of recalling words that begin with the letter "F", for 60 seconds. The final score will be determined according to the number of correct words reported in 60 seconds. In the semantic modality, participants must evoke as many animals as possible in 60 seconds. The final score will be determined according to the number of animal names reported in 60 seconds. |
| Measure | Description | Time Frame |
|---|---|---|
| Resting systolic and diastolic blood pressures [mmHg] | Resting systolic and diastolic blood pressures will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan). | Before and 10 minutes after the intervention |
| Resting heart rate [bpm] |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raphael Dias, PhD | University of Nove de Julho | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade Nove de Julho | São Paulo | 01504-001 | Brazil |
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One year after the completion
Upon request
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| ID | Term |
|---|---|
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D016138 | Walking |
| ID | Term |
|---|---|
| D008124 | Locomotion |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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The evaluator of flow-mediated dilation is blinded
| Break of sedentary behavior with walking | Other | Patients will interrupt sedentary behavior performing walking |
|
| Before and 35 minutes after the intervention |
Resting heart rate will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan). |
| Before and 10 minutes after the intervention |
| Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg] | The systolic, diastolic, and mean blood pressures during 24 hours will be measured using a non-invasive oscillometric device (Dynamapa) | 45 minutes after the intervention |
| Vascular function [%] | Vascular function will be measured with the flow-mediated dilation according to the global recommendations on popliteal artery before and after 15 minutes of intervention by a bidimensional ultrasonography device with spectral Doppler and linear transducer. | Before and 10 minutes after the intervention |
| D015444 | Exercise |
| D009043 | Motor Activity |