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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01DK125348 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
| Penn State University | OTHER |
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The goal of PrepareD is to examine whether the prepregnancy weight-loss intervention administered during the Prepare trial [NCT02346162] has an influence in the postnatal period. PrepareD is a cohort study (no intervention) that will address new specific aims through one in-person visit with mothers and children, dietary recalls, actigraphy, and the use of medical record weights. The goal is to collect data when the child is 3 years old. However, due to the COVID-19 pandemic, the investigators expanded the data collection window in order to collect data up to when the child is 5 years old. The investigators hypothesize that intervening on women before pregnancy is the key to breaking the multigenerational cycle of obesity.
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| Measure | Description | Time Frame |
|---|---|---|
| Child body mass index (BMI) from birth up to 5 years of age | All child weights, lengths (before age 2), and heights (after age 2) recorded in the electronic medical record (EMR) between delivery and up to 5 years of age will be collected. Child weight and height between 3 years 0 months of age up until 5 years of age will be measured at an in-person research visit. Weight in kilograms (kg) and height in meters (m) will be combined to report BMI in kg/m^2. | Birth up to 5 years of age |
| Mother postpartum weight retention (PPWR) in pounds at 5 weeks and 1 year postpartum | All weights recorded for the mother in the EMR between delivery and up to 5 weeks and 1 year postpartum will be collected. PPWR at 5 weeks and 1 year after delivery will be obtained by subtracting mother's 5-week postpartum weight (in lbs) and 1-year postpartum weight (in lbs) from mother's weight (in lbs) at delivery, respectively. | 5 weeks and 1 year after delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Healthy Eating Index (HEI) score for mother and child | Mother and child dietary data will be collected via dietary recalls following the study visit in order to calculate HEI total and component scores for mother and child. | At study visit, when child is 3-4 years of age |
| Daily activity level for mother and child |
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Inclusion Criteria:
Exclusion Criteria: None
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Participants for PrepareD will be recruited from the pool of women who consented to participate in the Prepare trial [NCT02346162]. The investigators expect to re-enroll around 180 Prepare mother-offspring pairs in the PrepareD study.
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| Name | Affiliation | Role |
|---|---|---|
| Erin S LeBlanc, MD, MPH | Kaiser Permanente | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaiser Permanente Center for Health Research | Portland | Oregon | 97227 | United States |
Any information from this study presented in reports or publications will not identify any individual.
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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blood, saliva, stool
Mother and child activity level will be collected via actigraphy. |
| At study visit, when child is 3-4 years of age |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |