Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) s.c. in Doses 2.4/2.4 mg and 1.0/1.0 mg Once Weekly Versus Semaglutide 2.4 mg and 1.0 mg, Cagrilintide 2.4 mg and Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor
Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) s.c. in Doses 2.4/2.4 mg and 1.0/1.0 mg Once Weekly Versus Semaglutide 2.4 mg and 1.0 mg, Cagrilintide 2.4 mg and Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Metformin With or Without an SGLT2 Inhibitor
The study will look at how well CagriSema helps people lower their blood sugar and body weight. CagriSema is a new weekly medicine that combines two medicines called semaglutide and cagrilintide. CagriSema will be compared to the two medicines semaglutide and cagrilintide, when they are taken alone. CagriSema will also be compared to a "dummy" medicine without any active ingredient. The study will be done in participants who have type 2 diabetes. Participants will take the study medicine together with the current diabetes medicine (metformin with or without an SGLT2 inhibitor).
Inclusion Criteria:
Exclusion Criteria:
CABA, Buenos Aires C1128 AAF, Argentina
CABA, City of Buenos Aires C1180AAX, Argentina
CABA, C1061AAS., Argentina
Fitzroy, Victoria 3065, Australia
Beijing, Beijing Municipality 100050, China
Beijing, Beijing Municipality 100853, China
Nanjing, Jiangsu 210011, China
Ji'Nan, Shandong 250000, China
Plzeň 3, 301 00, Czechia
Nea Efkarpia, Thessaloniki 56429, Greece
Budapest, Pest County 1036, Hungary
Vijaywada, Andhra Pradesh 520002, India
Herzeliya, Israel 4630945, Israel
Rome, 00168, Italy
Verona, 37126, Italy
Koriyama-shi, Fukushima, Fukushima, Japan 963-8851, Japan
Oita-shi, Oita,, Japan 870 0039, Japan
Chiba-shi, Chiba, 260-0804, Japan
Mito-shi, Ibaraki, 311-4153, Japan
Osaka-shi, Osaka, 530-8480, Japan
Mexicali, Estado de Baja California 21200, Mexico
Gorzów Wielkopolski, Lubusz Voivodeship 66-400, Poland
Bialystok, Podlaskie Voivodeship 15-435, Poland
Dąbrowa Górnicza, Silesian Voivodeship 41-300, Poland
Tychy, Silesian Voivodeship 43-100, Poland
Dąbrowa Górnicza, 41-300, Poland
Lodz, Łódź Voivodeship 93-513, Poland
Bucharest, Bucurestii 020475, Romania
Zalău, Sălaj County 450112, Romania
Kragujevac, 34000, Serbia
Paarl, Cape Town, Western Cape 7646, South Africa
Bucheon-si, Gyeonggi-do 14647, South Korea
La Roca Del Vallés, Barcelona 08430, Spain
Eskişehir, 26040, Turkey (Türkiye)
Istanbul, 34371, Turkey (Türkiye)
Istanbul, 34390, Turkey (Türkiye)