Effects of Cacao Flavonoids in Long COVID-19 Patients (FLALOC)

Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC)

The study use a triple blind, placebo-controlled design enrolling male and female subjects between 30-70 yo to evaluate the effect of daily consumption of a cacao supplement on inflammation, endothelial damage, handgrip strength, fatigue scale and quality of life.

The study use a triple blind, placebo-controlled design enrolling male and female subjects between 30-70 yo distributed homogeneously at random in two groups: the control group (Placebo) and the intervention group (Cacao Flavonoids) both groups affected for 90 days.

The variables to consider will be: Interleukins (IL-1b, IL-6), Tumoral Necrosis Factor alpha (TNF-α) and syndecan-1.

For physical performance is evaluated the handgrip strength. The investigators also assessed quality of life using the Health Related QoL (EQ-5D) questionnaire, and the numerical fatigue rating scale.

Inclusion Criteria:

• Post-COVID-19 patients, at least 6 months after symptom onset
• Chronic fatigue

Exclusion Criteria:

• Allergy or intolerance caused by active ingredients
• Pregnancy or lactation
• BMI >35
• chronic liver disease
• chronic kidney disease