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To investigate the incretin effect and postprandial incretin responses in plasma in patients with psoriasis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Psoriasis |
| ||
| Control | Age, Sex and BMI matched |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral glucose tolerance test | Diagnostic Test | Oral glucose tolerance test 50g |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incretin effect measured with Beta-cell secretory response | Incretineffect (%) = 100 % × (Beta-cell Secretory Response (OGTT) - Beta-cell Secretory Response (IIGI)) / Beta-cell Secretory Response (OGTT) | 0-180 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Insulin sensitivity measures | Matsudas insulin sensitivity index: (10,000 / √glucose minute 0 x insulin minute 0) (mean glucose (OGTT) x mean insulin OGTT)) | 0-180 minutes |
| Concentration of Glucose-independent insulinotropic polypeptide |
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Inclusion Criteria:
no diabetes BMI < 27 kg/m^2 normal Glucose tolerance test at screening normal fasting plasma glucose no islet auto antibodies no hormonel contraception informed consent psoriasis vulgaris (PASI>8) (case not controls)
Exclusion Criteria:
other chronic inflammtory skin disease other chronic inflammatory disease pregnancy psychiatric illness
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Cases with psoriasis vulgaris (PASI>8) Controls with no existing skin disease. Matched for Age, BMI and Sex
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38035766 | Derived | Lauritsen JV, Bergmann N, Junker AE, Gyldenlove M, Skov L, Gluud LL, Hartmann B, Holst JJ, Vilsboll T, Knop FK. Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response. Eur J Endocrinol. 2023 Dec 6;189(6):619-626. doi: 10.1093/ejendo/lvad161. |
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| ID | Term |
|---|---|
| D005951 | Glucose Tolerance Test |
| ID | Term |
|---|---|
| D001774 | Blood Chemical Analysis |
| D019963 | Clinical Chemistry Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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| Intravenous isoglycaemic glucose clamp | Other | Intravenous isoglycaemic glucose clamp |
|
| Liquid Mixed meal test | Other | Liquid Mixed meal test 520 kcal |
|
Evaluted as Area Under the Curve
| 0-180 minutes |
| Concentration of Glucagon-like peptide 1 | Evaluated as Area Under the Curve | 0-180 minuntes |
| Concentration of Glucagon | Evaluated as Area Under the Curve | 0-180 minutes |
| Concentration of Insulin | Evaluated as Area Under the Curve | 0-180 minutes |
| D003933 | Diagnosis |
| D003940 | Diagnostic Techniques, Endocrine |
| D008919 | Investigative Techniques |