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A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.
A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength (HGS) and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET).
Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiorespiratory fitness (CRF) - VO2 max | CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test. | Single time-point - 8 to 12 minutes |
| Cardiorespiratory fitness (CRF) - Anaerobic threshold | CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test. | Single time-point - 8 to 12 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle architecture - muscle thickness | Analysis of vastus lateralis muscle thickness using b-mode ultrasonography | Single time-point: 10 minutes |
| Muscle architecture - pennation angle | Analysis of vastus lateralis pennation angle using b-mode ultrasonography |
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Inclusion Criteria:
Exclusion Criteria:
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Community dwelling adults over the age of 65y who were able to provide written, informed consent and had no contraindications to exercise testing.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre of Metabolism, Ageing and Physiology (COMAP), University of Nottingham | Derby | Derbyshire | DE22 3DT | United Kingdom |
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| Single time-point: 10 minutes |
| Muscle architecture - fascicle length | Analysis of vastus lateralis fascicle length using b-mode ultrasonography | Single time-point: 10 minutes |