200 adult patients with multiple myeloma receiving teclistamb will be included. Effectiveness, safety, and condition of use of teclistamab in early access program (post-MA) will be assessed. Primary objective is the evaluation of overall response rate (ORR) of teclistamab according to IMWG criteria.

This is a multicenter, prospective, observational study.

Inclusion Criteria:

• Adult patient (≥18 years) with multiple myeloma who will receive at least one dose of teclistamab (first dose of the step-up dose)

Exclusion Criteria:

• Patients alive at the start of the study who did not receive study information or who objected to the collection of data
• Patients who received teclistamab as part of an interventional clinical trial
• Patients who are initiating teclistamab as part of a current interventional clinical trial

French adult patient relapsed and refractory multiple myeloma receving teclistamab