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The objective of the study is to evaluate the functional benefit of left bundle branch of His pacing compared to right ventricular pacing in patients implanted with a pacemaker prior to a atrioventricular node ablation procedure for rapid atrial fibrillation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| left bundle branch of His pacing (LBTP) then right ventricular pacing (RVP) | Experimental |
| |
| right ventricular pacing (RVP) then left bundle branch of His pacing (LBTP) | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| left bundle branch of His pacing | Procedure | left bundle branch of His pacing |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximum Oxygen Consumption (VO2 max) in mL/min/kg. | 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| walking test distance covered | 18 months | |
| echography criteria: LVEF (%), indexed left ventricular end-systolic volume (mL/m2), indexed cardiac output (L/min/m2), inter-ventricular asynchrony criteria (aortic pre-ejection time - pulmonary pre-ejection time) |
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Inclusion Criteria:
1/ Pacemaker implanted patient with LBTP lead and back-up right ventricular lead who subsequently underwent successful atrioventricular node ablation for rapid AF 2) NAV ablation procedure performed less than 15 days ago 3) Age ≥ 18 years 4) Woman of childbearing age with effective contraception (estrogen-progestin or intrauterine device or tubal ligation) for at least 1 month and for the duration of the study, and a negative urine pregnancy test by B-HCG at inclusion Or, Postmenopausal woman: confirmatory diagnosis (non-medically induced amenorrhea for at least 12 months prior to the inclusion visit).
5) Membership of a social security scheme 6) Patient follow-up feasible 7) Patient has read and understood the information leaflet and signed the informed consent form
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Corentin CHAUMONT, MD | Contact | 232888116 | +33 | corentin.chaumont@chu-rouen.fr |
| Armelle GUIDOTTI | Contact | 232888265 | +33 | armelle.guidotti@chu-rouen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Corentin CHAUMONT, MD | University Hospital, Rouen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de CAEN | Recruiting | Caen | France |
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| right ventricular pacing | Procedure | right ventricular pacing |
|
| 18 months |
| Determination of NT pro BNP or BNP | 18 months |
| Physical component of quality-of-life scale (SF-36) | 18 months |
| Medico-economic criteria: incremental cost-utility ratio of LBTP versus RVP | 18 months |