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| Name | Class |
|---|---|
| Jiangxi Center for Disease Control and Prevention | UNKNOWN |
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This study was conducted on the basis of "Safety Observation of Sabin Strain Inactivated Polio Vaccine (Vero Cell) on primary Immunization, Booster Immunization and Simultaneous Vaccination with Other Vaccines in Infants and Young Children(ID: PRO-sIPV-MA4001-JX). Blood samples were collected in about 200 qualified subjects 1-9 months after their last vaccination of sIPV. And immunogenicity of sIPV and other vaccines simultaneously administrated will be tested, the antibodies against enterovirus (including EV71、CA16、CA6 and CA10) will also be tested.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 2-3 months infants group | Subjects in this group had recieved three dose of sIPV as primay immunization, and about half of them recieved DTaP simultaneously. |
| |
| 18 months children group | Subjects in this group had recieved one dose of sIPV as booster immunization, and about half of them recieved MMR or hepatitis A vacine(live-attenuated or inactivated) simultaneously. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other | This is an observation study after vaccination, no intervention will be used |
|
| Measure | Description | Time Frame |
|---|---|---|
| Antibody positivity rate of sIPV vaccine after primary immunization in infants | 1 month | |
| Antibody positivity rate of sIPV after booster immunization with sIPV vaccine in young children | 1 month | |
| seropositive rate of antibodies against different enteroviruses (EV71/CA16/CA6/CA10) in infants and young children | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| GMT of sIPV vaccine after primary immunization in infants | 1 month | |
| GMT of sIPV after booster immunization with sIPV vaccine in young children | 1 month | |
| GMT of antibodies against different enteroviruses |
| Measure | Description | Time Frame |
|---|---|---|
| Antibody positivity rate and GMC for pertussis, diphtheria and tetanus after full vaccination with DTaP vaccine in infants | 1 month | |
| Antibody positivity rate and GMC of hepatitis A vaccine after full vaccination in young children | 1 month |
Inclusion Criteria:
Exclusion Criteria:
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Subjects in the Primay immunization group(aged 2-3 months) need to complete 3 doses of sIPV vaccination, and the simultaneous vaccination group DTaP needs to complete 3 doses of vaccination; the booster immunity group(aged more than 18 months) needs to complete sIPV vaccination, and the simultaneous vaccination group needs to complete the corresponding vaccination
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jiangxi Center for Disease Control and Prevention | Nanchang | Jiangxi | 330029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39088987 | Derived | Guo S, Li Z, Zheng M, Wu F, Sun J, Tuo L, Li S, Li X, Wei L, Xia Z, Xie P, Chen X, Zhao Y, Gao Y, Yu D. Safety and 6-month immune persistence of inactivated poliovirus vaccine (Sabin strains) simultaneously administrated with other vaccines for primary and booster immunization in Jiangxi Province, China. Vaccine. 2024 Aug 30;42(21):126183. doi: 10.1016/j.vaccine.2024.126183. Epub 2024 Jul 31. |
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| ID | Term |
|---|---|
| D011051 | Poliomyelitis |
| ID | Term |
|---|---|
| D009187 | Myelitis |
| D002494 | Central Nervous System Infections |
| D007239 | Infections |
| D004769 | Enterovirus Infections |
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| 1 month |
| Antibody positivity rate and GMT for measles, rubella, and mumps after full vaccination of MMR vaccine in young children | 1 month |
| D010850 |
| Picornaviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D013118 | Spinal Cord Diseases |
| D000090862 | Neuroinflammatory Diseases |
| D009468 | Neuromuscular Diseases |