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| ID | Type | Description | Link |
|---|---|---|---|
| ANR-21-CE17-0031 | Other Grant/Funding Number | ANR | |
| 2022-A01949-34 | Other Identifier | IDRCB |
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| Name | Class |
|---|---|
| University Grenoble Alps | OTHER |
| Institut National de la Santé Et de la Recherche Médicale, France | OTHER_GOV |
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The goal of EPI-CATCHER is to outline the clinical potential of multiparametric quantitative MRI (mqMRI) and of GABA-edited magnetic resonance spectroscopy (GABA-MRS), combined with machine learning tools, as imaging biomarkers to localize and delineate the EZ.
After informed consent, patient candidate to resection surgery will undergo two extra MRI sessions before surgery: one for multiparametric quantitative MRI (mqMRI) and one for GABA-edited magnetic resonance spectroscopy (GABA-MRS) In parallel, a group of healthy volunteers will also undergo the two MRI sessions described above, to collect reference data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | mqMRI and GABA-MRS data will be collected in patients suffering from mesial temporal lobe epilepsy |
| |
| Volunteers | mqMRI and GABA-MRS data will be collected in healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| mqMRI and GABA-MRS | Diagnostic Test | multiparametric quantitative MRI (mqMRI) and of GABA-edited magnetic resonance spectroscopy (GABA-MRS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| EZmri vs EZsdt | The correlation coefficient between the Dice similarity coefficient (= 2 * the Area of Overlap between EZMRI and EZsdt divided by the total number of pixels in EZMRI and EZsdt) and the reduction in seizure frequency (= seizure frequency one year after surgery / seizure frequency at inclusion). | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| mqMRI : T1 (ms) | Compare, for each patient, the mqMRI parameter values measured in the EZsdt with the mean mqMRI parameter values obtained in the same region across the healthy volunteers | 5 years |
| mqMRI : T2 (ms) |
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Inclusion Criteria:
Patient group
Reference group
Exclusion Criteria:
Patient group
Reference group
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Group 1 : patients with MTLE epilepsy, candidate to resection surgery Group 2 : healthy volunteers, to obtain reference mqMRI and GABA-MRS values
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lucie Miquel, MSc | Contact | +33 4 76 76 63 08 | lmiquel@chu-grenoble.fr | |
| Emmanuel L Barbier, PhD | Contact | emmanuel.barbier@univ-grenoble-alpes.fr |
| Name | Affiliation | Role |
|---|---|---|
| Philippe Kahane, MD, PhD | University Grenoble Alps | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33818790 | Background | Boux F, Forbes F, Collomb N, Zub E, Maziere L, de Bock F, Blaquiere M, Stupar V, Depaulis A, Marchi N, Barbier EL. Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy. Epilepsia. 2021 May;62(5):1244-1255. doi: 10.1111/epi.16886. Epub 2021 Apr 5. | |
| 33258489 |
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| ID | Term |
|---|---|
| D004833 | Epilepsy, Temporal Lobe |
| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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Brain resected tissue
Compare, for each patient, the mqMRI parameter values measured in the EZsdt with the mean mqMRI parameter values obtained in the same region across the healthy volunteers
| 5 years |
| mqMRI : Mean Diffusivity (s/mm²) | Compare, for each patient, the mqMRI parameter values measured in the EZsdt with the mean mqMRI parameter values obtained in the same region across the healthy volunteers | 5 years |
| mqMRI : Cerebral Blood Volume (%) | Compare, for each patient, the mqMRI parameter values measured in the EZsdt with the mean mqMRI parameter values obtained in the same region across the healthy volunteers | 5 years |
| mqMRI : Blood-Brain Barrier Permeability (%) | Compare, for each patient, the mqMRI parameter values measured in the EZsdt with the mean mqMRI parameter values obtained in the same region across the healthy volunteers | 5 years |
| GABA | Compare, for each patient, the amplitude of GABA and other metabolites available using proton MRS (N-acetyl aspartate and N-acetyl-aspartyl-glutamate (NAA) Creatine and phosphocreatine (Cr), Choline (Cho), Myo-inositol, myo-inositol-monophosphate and glycine (mI), Glutamine (Gln), glutamate (Glu), Lipids (LipX), Lactate (Lac)) in the EZsdt with the mean values obtained in the same region across the healthy volunteers | 5 years |
| Hamelin S, Stupar V, Maziere L, Guo J, Labriji W, Liu C, Bretagnolle L, Parrot S, Barbier EL, Depaulis A, Fauvelle F. In vivo gamma-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach. Epilepsia. 2021 Jan;62(1):163-175. doi: 10.1111/epi.16768. Epub 2020 Dec 1. |
| D009422 |
| Nervous System Diseases |
| D000073376 | Epileptic Syndromes |