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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
PRIMARY OBJECTIVES:
I. To conduct a descriptive study of same sex twins (MZ and DZ) discordant for childhood CNS tumors identified through the Children's Oncology Group Project:EveryChild registry.
II. To compare the prevalence of somatic mosaicism in classic cancer-associated genes in monozygotic (MZ) twins discordant for childhood brain tumors. In our pilot study, we will sequence blood and saliva DNA samples from 25 MZ twin pairs using a panel of 94 known cancer associated genes.
SECONDARY OBJECTIVES:
I. To compare the profile of mutations detected in DNA extracted from pre- and post-treatment blood samples from a subset of CNS tumor patients. The purpose of this aim is to ensure that differences in somatic mosaicism detected in twin pairs are not caused by cancer therapy.
Outline:
Twins with CNS tumors will undergo blood and saliva DNA samples with the goal is to learn more about genetic differences that may lead to CNS tumor development.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ancillary-Correlative | Twins with CNS tumors, identified through the Children's Oncology Group's Project:EveryChild (PEC) registry, will have both blood and saliva samples collected at the time of study enrollment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biospecimen collection | Other | Collection of both blood and saliva samples from participants at the time of study enrollment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare the prevalence of somatic mosaicism in classic cancer-associated genes in monozygotic (MZ) twins discordant for childhood brain tumors. | Sequence blood and saliva DNA samples from 25 MZ twin pairs using a panel of 94 known cancer associated genes. | Up to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the profile of mutations detected in DNA extracted from pre- and post-treatment blood samples from a subset of CNS tumor patients. | Determine the frequency of somatic mosaicism in twins discordant for CNS tumors. Will use an exact test of proportions to determine whether the affected twin is more likely to have a mosaic mutation. The comparison of pre-treatment and post-treatment samples in the CNS tumor cases will include a descriptive comparison of the mutations identified in each sample |
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Inclusion Criteria:
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Newly diagnosed same sex twins with pediatric central nervous system (CNS) tumors
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jenny Poynter, PhD | Contact | (612) 625-4232 | poynt006@umn.edu |
| Name | Affiliation | Role |
|---|---|---|
| Jenny Poynter, PhD | University of Minnesota | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Recruiting | Minneapolis | Minnesota | 55455 | United States |
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| ID | Term |
|---|---|
| D016543 | Central Nervous System Neoplasms |
| ID | Term |
|---|---|
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009422 | Nervous System Diseases |
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| Questionnaire Administration | Other | The brief questionnaire will assess health history, demographics, environmental exposures, family history of cancer, and birth characteristics. |
|
| Up to 18 months |