Diphtheria Antitoxin (DAT)

Administered intravenously.

Dosage:

• Mild diphtheria (nose, skin): 20,000 unit
• Moderate diphtheria (tonsil - limited): 40,000 - 60,000 unit
• Severe diphtheria (more than 1 tonsil, or to the pharyngeal wall, or more than 5 days of illness, or with bull neck): 80,000 - 120,000 unit

Dosage form: Solution for injection

Dosage:

1. Perform sensitivity tests, and desensitization if necessary.

2. Give the entire treatment dose of antitoxin IV (or IM) in a single administration (except for series of injections needed for desensitization).

3. The recommended DAT treatment dosage ranges (pediatric and adult) are:

   • Pharyngeal or laryngeal disease of 2 days duration 20,000 - 40,000 unit
   • Nasopharyngeal disease 40,000 - 60,000 unit
   • Extensive disease of 3 or more days duration, or any patient with diffuse swelling of neck 80,000 - 100,000 unit
   • Skin lesions only (rare case where treatment is indicated) 20,000 - 40,000 unit

Percentage of serum sickness after administration of Diphtheria Antitoxin (DAT)

Percentage of local and systemic reaction after administration of Diphtheria Antitoxin (DAT)