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| Name | Class |
|---|---|
| University of Abuja Teaching Hospital | OTHER |
| Aminu Kano Teaching Hospital | OTHER |
| Murtala Muhammad Specialist Hospital | OTHER |
| National Hospital, Abuja |
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The goal of this study is to evaluate the use of aspirin for the prevention of preeclampsia among moderate -to- high-risk pregnant women in tertiary care hospitals in Nigeria followed by a qualitative study to evaluate the barriers and facilitators of aspirin use in prenatal care for the prevention of preeclampsia in Nigeria. The main question[s] it aims to answer are:
Nigeria has the highest burden of maternal mortality worldwide accounting for over 1 in 4 of global maternal deaths. In a 2022 nationwide analysis of maternal outcomes in 76,563 deliveries across referral-level hospitals in Nigeria, hypertensive disorders of pregnancy (HDP) including preeclampsia accounted for 32% of maternal deaths. Studies have linked the pathophysiology of preeclampsia to peripartum cardiomyopathy (PPCM) which is prevalent in Nigeria.5,6 Patients with PPCM were 4 times as likely to have preeclampsia that patients without PPCM. Among known evidence-based interventions for HDP, aspirin prophylaxis stands out as among the most highly effective in preeclampsia prevention. A comprehensive understanding of utilization patterns, or lack thereof, as well as the identification of barriers and facilitators, can inform implementation studies aimed at increasing adoption of this highly effective and cost-effective intervention.
Aims:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| University of Abuja Teaching Hospital | Pregnant women with Hypertensive Disorder of Pregnancy who seek care in the Federal Capital Territory, attending antenatal clinics on the 2nd or subsequent visit and pregnant women presenting to the labor and delivery room. |
| |
| Amino Kano Teaching Hospital | Pregnant women with Hypertensive Disorder of Pregnancy who seek care in Kano State in Nigeria, attending antenatal clinics on the 2nd or subsequent visit and pregnant women presenting to the labor and delivery room. |
| |
| National Hospital, Abuja | Pregnant women with Hypertensive Disorder of Pregnancy who seek care in the Federal Capital Territory, attending antenatal clinics on the 2nd or subsequent visit and pregnant women presenting to the labor and delivery room. |
| |
| Murtala Muhammad Specialist Hospital | Pregnant women with Hypertensive Disorder of Pregnancy who seek care in Kano State in Nigeria, attending antenatal clinics on the 2nd or subsequent visit and pregnant women presenting to the labor and delivery room. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure of interest - Moderate or High-risk Preeclampsia | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Aspirin Use Proportion | Proportion of women (participants) at moderate- or high-risk of preeclampsia who report aspirin use. | 12 weeks- 42 weeks gestation |
| Measure | Description | Time Frame |
|---|---|---|
| Moderate or High-risk Preeclampsia Proportion. | Proportion of women at moderate- to high-risk of preeclampsia among those attending antenatal care who are participants. | Throughout study duration, from 2nd antenatal visit or after 12 weeks' gestation |
| Measure | Description | Time Frame |
|---|---|---|
| Preeclampsia or Eclampsia proportion categorized as moderate or high risk | Proportion of women presenting with preeclampsia or eclampsia at delivery who would have been categorized as moderate or high- risk at antenatal care visits out of the entire cohort of pregnant participants. | Throughout study duration, from 2nd antenatal visit or after 12 weeks' gestation |
Inclusion Criteria:
Exclusion Criteria:
Females who are pregnant
Pregnant women attending antenatal clinic or presenting to the labor ward at 2 tertiary and 2 secondary health facilities in the Federal capital territory and Kano state of Nigeria.
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| Name | Affiliation | Role |
|---|---|---|
| Mark Huffman, MD MPH | Washington University School of Medicine | Principal Investigator |
| Dike Ojji, MBBS PhD | University of Abuja Teaching Hospital | Principal Investigator |
| Kathryn Lindley | Vanderbilt University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Hospital, Abuja | Abuja | Nigeria | ||||
| University of Abuja Teaching Hospital |
IPD will be available within 1 year of study completion.
Data will be available within 1 year of study conclusion
After completion of this study, to ensure that our results are used by researchers, policymakers, and community-based organizations, we will disseminate our results through the following:
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| OTHER_GOV |
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| Gwagwalada |
| Nigeria |
| Aminu Kano Teaching Hospital | Kano | Nigeria |
| Murtala Muhammad Specialist Hospital | Kano | Nigeria |