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The aim of the study is to assess the common risk factors for development of hospital acquired acute kidney injury among hospitalized patients in Alexandria Main University hospital and their outcomes.
Hospital-acquired AKI (HAAKI) is defined as acute renal insult occurring 48 hours or more after admission to a health care facility and It is estimated to occur in 13-18% of hospitalized patients. The early diagnosis of HAAKI reflects on improvement in morbidity and mortality rates especially in developing countries which goes parallel with the goal The International Society of Nephrology (ISN) to eliminate preventable or treatable deaths from AKI by 2025, the "0 by 25" initiative.
Data concerning the spectrum of acute kidney injury (AKI) in Egypt are generally scarce.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AKI group | patients who are hospitalized and develop acute kidney injury after 48 hours from admission |
| |
| no AKI group | patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| standard AKI care bundle | Other | AKI care bundle include use of iv fluids, diuretics, antihyperkalemic drugs, sodium bicarbonate, antibiotics in septic patients. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recovery of kidney functions | (improvement of eGFR, serum creatinine to normal or previous baseline). | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| progression to chronic kidney disease. | deterioration of kidney functions ( creatinine, eGFR) | 12 weeks |
| mortality | death | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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This research is a prospective cohort study that will include hospitalized patients in Alexandria Main University Hospital (in non-intensive care unit sittings) admitted over a period of sixteen weeks.
Patients will be divided into two groups:
Group (A) : patients who are hospitalized and develop acute kidney injury after 48 hours from admission.
Group (B) : patients who are hospitalized and do not develop acute kidney injury after 48 hours from admission till discharge.
All participants will be followed till discharge and after 3 months to assess outcomes.
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| Name | Affiliation | Role |
|---|---|---|
| Hala S ElWakil, MD | professor | Principal Investigator |
| yasmine s naga, MD | ASS. prof | Study Chair |
| Mohamed mamdouh Elsayed, MD | Lecturer | Study Chair |
| sara R Nagib, MBBCh | Resident | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine, Aexandria University | Alexandria | 21526 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23580801 | Background | Singh TB, Rathore SS, Choudhury TA, Shukla VK, Singh DK, Prakash J. Hospital-acquired acute kidney injury in medical, surgical, and intensive care unit: A comparative study. Indian J Nephrol. 2013 Jan;23(1):24-9. doi: 10.4103/0971-4065.107192. | |
| 25564144 | Background | Sawhney S, Mitchell M, Marks A, Fluck N, Black C. Long-term prognosis after acute kidney injury (AKI): what is the role of baseline kidney function and recovery? A systematic review. BMJ Open. 2015 Jan 6;5(1):e006497. doi: 10.1136/bmjopen-2014-006497. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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| standard care for hospitalized patients | Other | this includes iv fluids, diuretics, antibiotics in septic patients, other measures according to original disease |
|
| Need for renal replacement therapy | different modalities of RRT | 12 weeks |
| 27175701 | Background | Hsu CN, Lee CT, Su CH, Wang YL, Chen HL, Chuang JH, Tain YL. Incidence, Outcomes, and Risk Factors of Community-Acquired and Hospital-Acquired Acute Kidney Injury: A Retrospective Cohort Study. Medicine (Baltimore). 2016 May;95(19):e3674. doi: 10.1097/MD.0000000000003674. |
| 27578995 | Background | Ponce D, Balbi A. Acute kidney injury: risk factors and management challenges in developing countries. Int J Nephrol Renovasc Dis. 2016 Aug 22;9:193-200. doi: 10.2147/IJNRD.S104209. eCollection 2016. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |