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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-A01332-41 | Registry Identifier | ID RCB |
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Introduction:
Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.
Aim:
In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.
Method:
Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group.
Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GTS group | Experimental | This arm will be studied to get some electrophysiological marker of tics. The patients will be their own control (periods with symptoms vs. free symptoms periods). |
|
| OCD group | Experimental | This arm will be studied to get some electrophysiological marker of compulsions. The patients will be their own control (periods with symptoms vs. free symptoms periods). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EEG | Device | Recording, from the scalp, the electrophysiological activity of the brain. |
|
| Measure | Description | Time Frame |
|---|---|---|
| modification of power (μV2) in EEG frequencies before compulsions in Obsessive-Compulsive Disorder patients | change in the power EEG frequencies in OCD patients before compulsions EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations | one year |
| modification of power (μV2) in EEG frequencies before tics in Gilles de la Tourette patients | change in the power of EEG frequencies in GTS patients before tics EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in power (μV2) in EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients | Difference in the power in the EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations | One year and a half |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luc MALLET, MD | Contact | +33157274000 | luc.mallet@inserm.fr | |
| Hugues LAMOTHE, MD | Contact | +33149813195 | lamothehugues@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Luc MALLET, MD | Assistance Publique - Hôpitaux de Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Albert Chenevier | Recruiting | Créteil | 94000 | France |
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| ID | Term |
|---|---|
| D013981 | Tic Disorders |
| D005879 | Tourette Syndrome |
| ID | Term |
|---|---|
| D009069 | Movement Disorders |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D065886 | Neurodevelopmental Disorders |
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| ID | Term |
|---|---|
| D004569 | Electroencephalography |
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
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| MRI | Device | Get the anatomical shape of the brain. |
|
|
| percentage (%) of compulsions and tics detected by accelerometer | percentage of compulsions and tics detected by accelerometer | One year and a half |
| Correlation of EEG frequency power (arbitrary units) detected before compulsions and scores get with clinical scales (Y-BOCS) | Correlation between power in EEG frequencies and Y-BOCS score get by each individual patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms | One year and a half |
| Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients | Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms | One year and a half |
| Hôpital Henri Mondor | Recruiting | Créteil | 94010 | France |
|
| Hôpital Pitié Salpêtrière | Recruiting | Paris | 75013 | France |
|
| D001523 | Mental Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |