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| ID | Type | Description | Link |
|---|---|---|---|
| J3P-MC-FTAE | Other Identifier | Eli Lilly and Company |
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The main purpose of this study is to evaluate how much of the study drug (LY3871801), administered as a single dose that has the radioactive substance 14C incorporated into it, passes from blood into urine, feces and expired air in healthy male participants. The study will also measure how much of the study drug gets into the bloodstream, how its broken down, and how long it takes the body to get rid of it. The study will last up to approximately 9 weeks including the screening period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| [14C]-LY3871801 | Experimental | Single dose of [¹⁴C]-LY3871801 administered orally |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [14C]-LY3871801 | Drug | Administered orally |
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| Measure | Description | Time Frame |
|---|---|---|
| Urinary Excretion of LY3871801 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered | Urinary Excretion of LY3871801 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered | Predose up to Day 7 post dose |
| Fecal Excretion of LY3871801 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered | Fecal Excretion of LY3871801 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered | Predose up to Day 7 post dose |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics (PK): Area Under the Concentration Curve Versus Time From zero to Infinity (AUC [0-∞]) of [¹⁴C]-LY3871801 | PK: AUC [0-∞] of [¹⁴C]-LY3871801 | Predose up to Day 7 post dose |
| PK: AUC [0-∞] of Total Radioactivity in Plasma and Whole Blood |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) | Eli Lilly and Company | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Covance Clinical Research Unit | Madison | Wisconsin | 53704 | United States |
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PK: AUC [0-∞] of Total Radioactivity in Plasma and Whole Blood |
| Predose up to Day 7 post dose |
| PK: Maximum Concentration (Cmax) of [¹⁴C]-LY3871801 | PK: Cmax of [¹⁴C]-LY3871801 | Predose up to Day 7 post dose |
| PK: Cmax of Total Radioactivity | PK: Cmax of Total Radioactivity | Predose up to Day 7 post dose |
| Total Radioactivity Recovered in Urine, Feces, and Expired Air | Total Radioactivity Recovered in Urine, Feces, and Expired Air | Predose up to Day 7 post dose |
| Total Number of Metabolites of LY3871801 | Total Number of Metabolites of LY3871801 | Predose up to Day 7 post dose |