Influence of Luteolin for Two Weeks on Memory in Healthy Subjects

Influence of the Dietary Supplement Luteolin for Two Weeks on Memory in Healthy Subjects

The goal of this clinical trial is to learn about the effect of the dietary supplement luteolin in healthy people. The main question it aims to answer is: Does luteolin have an influence on memory functions?

Participants will go trough two treatment phases. In one phase they will take 250mg luteolin twice daily for two weeks. In the other phase they will take a placebo twice daily for two weeks. A placebo is a look-alike substance that contains no active drug.

At the start and end of teach treatment phase, participants will undergo different memory testing exercises in our research facility.

Inclusion Criteria:

• healthy
• male or female
• able to give written informed consent as documented by signature
• Aged: 18 to 40 years
• normotensive (BP 90/60mmHg to 140/90mmHg)
• BMI ≤ 30 kg/m2

Exclusion Criteria:

• bodyweight <50 kg
• pregnant or lactating women
• intention to become pregnant during the course of the study
• known or suspected non-compliance, drug or alcohol abuse
• MADRS-S total score > 12 or MADRS-S item 9 >1
• inability to follow the procedures of the study, e.g. due to language problems, psychological disorders
• participation in another study with investigational drug within the 30 days preceding and during the present study
• participation in one of our previous studies using the same memory tests in the past 2 years or participation in our first luteolin study in 2020
• enrolment of the investigator, his/her family members, employees and other dependent persons