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Prevention and non pharmacological treatment of prehypertension and hypertension stage 1
The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in individuals with normotension and hypertension.
What does the study involve?
A. Resistance training protocol: 75% 1RM, 10 reps, 3 sets, 2 min rest between sets and exercises, 16 exercises
The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in individuals with normotension and hypertension.
Participants with normotension and hypertension (1 stage of hypertension), adult: 40 - 63 years old, physically active - no professional sportsman.
Participants with fluctuating blood pressure, with type 1 and type 2 diabetes mellitus, after a myocardial infarction, after a stroke, with an infectious disease, with grade 3 obesity, with hypertension II. - IV. degrees and individuals suffering from dizziness during exercise are excluded.
What does the study involve?
A. Resistance training protocol:
Benefits: health assessment, physical fitness testing, professional supervision of training.
Potential disadvantages: soreness and muscle strain, fatigue, dizziness, feeling sick.
The study is run in Pavel Kolar´s Centre of Physical Medicine and the Faculty of Physical Education and Sport, Charles University.
The study began in April 2022 and will run until December 31, 2023. Agonist-Antagonist resistance training with 75% 1 RM induces an similar decrease in systolic and diastolic blood pressure values after training sessions at the p<0.05 level, as aerobic (control) training in normotensive and hypertensive individuals (1 stage of hypertension).
Alternative hypothesis H1: Agonistic-Antagonist resistance training with 75% 1 RM will result in a smaller increase in systolic and diastolic blood pressure values after training sessions at the p<0.05 level, compared to traditional resistance training in sets in normotensive and hypertensive subjects (1 stage of hypertension).
Agonistic resistance training with 75% 1 RM will induce a similar increase in pulse wave velocity during the training sessions at the p <0.05 level as aerobic (control) training in normotensive and hypertensive subjects (1 stage of hypertension).
Alternative Hypothesis H2: Agonistic resistance training with 75% 1 RM will result in a statistically significantly greater increase in pulse wave velocity values during the training sessions at the p <0.05 level compared to traditional resistance training in sets in normotensive and hypertensive subjects (1 stage of hypertension).
Isolated exercises induce a similar increase in systolic and diastolic blood pressure values during resistance training in normotensive and hypertensive individuals (1 stage of hypertension) as aerobic (control) training.
Alternative hypothesis H3: Complex/multi-joint exercises will lead to statistically significantly higher increases in systolic and diastolic blood pressure values in normotensive and hypertensive subjects (1 stage of hypertension) compared to isolated exercises.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normotension group | Experimental | Participants with normotension Adult: 40 - 63 years old Physically active - no professional sportsman |
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| Hypertension Stage 1 group | Experimental | Participants with Hypertension Stage 1 Adult: 40 - 63 years old Physically active - no professional sportsman. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiovascular fitness | Behavioral | A randomized single-blind controlled trial tested the hypothesis that different variants of resistance training (antagonistic lower and upper body training, agonistic lower and upper body training, and aerobic training) have different effects on blood pressure (systolic and diastolic), aortic pulse wave velocity (PWVao), and augmentation index (Aix) values and compared subjects with normotension and hypertension during and after exercise session. |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial stiffness - Pulse wave velocity | Specifically, Aortic pulse wave velocity will be measured. The norm is up to 9 m/s, values above 9 m/s indicate impaired arterial stiffness. Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular events, dementia, and death. Decreased compliance of the central vasculature alters arterial pressure and flow dynamics and impacts cardiac performance and coronary perfusion. It is measured by Arteriograph (TensioMed, Budapest, Hungary). | The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours. |
| Blood pressure | Measurement of changes in blood pressure level. Increase in systolic and diastolic blood pressure (mm Hg) during resistance training for agonist-antagonist and traditional agonist resistance training. Blood pressure ranges: Normal: less than 120 systolic and 80 diastolic. Elevated: 120-129 systolic and less than 80 diastolic. Stage 1 hypertension: 130-139 systolic or 80-89 diastolic. Stage 2 hypertension: at least 140 systolic or at least 90 diastolic.Investigators are looking for the safest option of resistance training for individuals with hypertension. It is measured by Arteriograph (TensioMed, Budapest, Hungary). | The training takes place twice a week, 1 training session takes 60 minutes, the total number of sessions is 5. The total length of the program is 3 weeks, duration is 5 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Handgrip strength | Handgrip (kg) is measured by Takei (TKK 5401, Japan).It will be measured for both hands (left and right). Three trials will be performed on each hand and the mean will be calculated. The standard for men over 40 years of age is 47 (±9.5) kg for the right hand and 45 (±9.3) kg for the left hand. The standard for women over 40 is 29 (±5.7) kg for the right hand and 28 (±5.7) kg for the left hand. Higher values are considered to be better. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pavel Kolar´s Centre of Physical Medicine | Prague | 148 00 | Czechia | |||
| The Faculty of Physical Education and Sport, Charles University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40087719 | Derived | Jurik R, Stastny P, Kolinger D, Gola A, Vetrovsky T. Blood pressure changes during different methods of resistance training in normotensive and stage 1 hypertensive individuals: a repeated measures cross-sectional study. BMC Sports Sci Med Rehabil. 2025 Mar 14;17(1):49. doi: 10.1186/s13102-025-01097-3. |
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Due to the sensitivity of the data (personal data), it has not been decided whether the data will be provided to third parties.
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Comparing two groups
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| before intervention, one session, it takes 10 minutes, week 1 |
| The concentration of total cholesterol | Total cholestero (mmol/l) is measured by NEXTCLINICS Czech a.s. The reference range is 2,90-5,00 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| Body mass index | BMI (kg/m2 ) is measured by InBody370S. Optimal values for BMI: 18.5-24.9 kg | before intervention, one session, it takes 15 minutes, week 1 |
| Harvard step test | The Harvard Step Test is used to measure a clients aerobic fitness, being a predictive test of their VO2max. It tests the cardiovascular system and reflects the general capacity of body to cope with increased physical work load and ability to recover from it. Values in steptest for untrained population: > 90 points: excellent, 80-89 points: good, < 65 - 79 points: average, 55 - 64 points: Poor, 65 - 79: low average. Higher values mean a better result. | before intervention, one session, it takes 8 minutes, week 1 |
| Abdominal wall tension | Abdominal wall tension is measured by OHMBelt (Nilus Medical LLC) . Increases in abdominal wall tension correlate with intra-abdominal pressure changes. It could be an approximate predictor of systolic blood pressure. | two measurements, 2x 60-90 minutes, week 1 |
| The Borg rating of perceived exertion | A modified Borg CR10 Scale will be used in this study. The subject will indicate the intensity of the exercise on a scale from 0 to 10. 0 means no exertion and 10 means maximum exertion. | The total length of the program is 3 weeks, total duration is 5 hours. The results are recorded after each series of exercises - total 8x |
| Repetition testing | Assessing the strength capacity of individuals in non-laboratory environments. It is simply defined as the maximal or submacimal weight an individual can lift for only one repetition with correct technique. We measured 15 RM, 10 RM, 5 RM, 5 RM and 1RM in normotensive individuals. | two measurements, 2x 60-90 minutes, week 1 |
| Fat mass | Fat mass (kg) is measured by InBody370S. | before intervention, one session, it takes 15 minutes, week 1 |
| Lean mass | Lean mass (kg) is measured by InBody370S. | before intervention, one session, it takes 15 minutes, week 1 |
| Body fat | Body fat (%) is measured by InBody370S. Optimal values for % body fat: age 40-59 - 23-33% body fat, age 60-79 - 24-35% body fat. | before intervention, one session, it takes 15 minutes, week 1 |
| Body weight | Body weight (kg) is measured by InBody370S. | before intervention, one session, it takes 15 minutes, week 1 |
| The concentration of low density lipoprotein (LDL) | LDL (mmol/l) is measured by NEXTCLINICS Czech a.s. The reference range is 1,2-3,00 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| The concentration of high density lipoprotein (HDL) | HDL (mmol/l) is measured by NEXTCLINICS Czech a.s. The reference range is 1,00-2,10 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| The concentration of triacylglycerols | Triacylglycerols (mmol/l) are measured by NEXTCLINICS Czech a.s. The reference range is 0,45-1,70 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| The concentration of c-reactive protein (CRP) | CRP (mg/l) is measured by NEXTCLINICS Czech a.s. The reference range is 0,0-8,0 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| Blood sugar level | Blood sugar (mmol/l) level is measured by NEXTCLINICS Czech a.s. The reference range is 3,30-5,59 mmol/l. | before intervention, one session, it takes 15 minutes, week 1 |
| Prague |
| 162 52 |
| Czechia |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
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