Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Surface mechanomyography (sMMG) has been proposed as a tool to study muscle mechanical activity. sMMG is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . It could be of major interest for the detection of respiratory efforts in patients with respiratory failure. This study aims at assessing the performances of sMMG to measure and detect respiratory drive and effort in healthy volunteers.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SV - R / SV + R / PSV | Experimental | Spontaneous ventilation without resistance (SV - R) / Spontaneous ventilation with resistance (SV + R) / Pressure support ventilation (PSV) |
|
| SV - R / PSV / SV + R | Experimental | Spontaneous ventilation without resistance / Pressure support ventilation / Spontaneous ventilation with resistance |
|
| SV + R / PSV / SV - R | Experimental | Spontaneous ventilation with resistance / Pressure support ventilation / Spontaneous ventilation without resistance |
|
| SV + R / SV - R / PSV | Experimental | Spontaneous ventilation with resistance / Spontaneous ventilation without resistance / Pressure support ventilation |
|
| PSV / SV + R / SV - R | Experimental | Pressure support ventilation / Spontaneous ventilation with resistance / Spontaneous ventilation without resistance |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-invasive ventilation with or without resistance | Device | non-invasive ventilation with or without resistance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of sMMG to detect respiratory effort | Delays between the beginning of the respiratory effort detected by sMMG and Eadi and the end of the respiratory effort detected by sMMG and Eadi (msec) | 5 minutes after the beginning of recording |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison between sMMG-time (MMG-TP) and PTPes-Pes Peak | Accuracy of sMMG to assess the intensity of respiratory effort (in comparison with pressure-time product in cm H2O.s.min-1) | 5 minutes after the beginning of recording |
| Comparison between sMMG slope & Eadi parameters |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Angers University Hospital | Angers | 49000 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D063087 | Noninvasive Ventilation |
| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012138 | Respiratory Therapy |
Not provided
Not provided
Esophageal pressure, electrical activity of the diaphram (Eadi) and sMMG will be recorded in 10 healthy subjects in spontaneous ventilation (SV) and non-invasive ventilation with or without resistance.
Not provided
Not provided
Recordings will be analysed by investigators blind to ventilation conditions
| PSV / SV - R / SV + R | Experimental | Pressure support ventilation / Spontaneous ventilation without resistance / Spontaneous ventilation with resistance |
|
Accuracy of sMMG to assess the intensity of respiratory drive (in comparison with Eadi in microvolt) |
| 5 minutes after the beginning of recording |
| Comparison between sMMG slope & slope Peso | Accuracy of sMMG to assess the intensity of respiratory drive (in comparison Peso in cm H20) | 5 minutes after the beginning of recording |
| Delay between neural time measured by sMMG and neural time measured by Eadi | Accuracy of sMMG to assess the duration of inspiratory neural time (in comparison with Eadi in msec) | 5 minutes after the beginning of recording |