Intrauterine Device Versus Uterine Artery Embolization for Adenomyosis

Intrauterine Device Versus Uterine Artery Embolization for Adenomyosis: A Randomized Controlled Trial Comparing Therapeutic Efficacy

The primary purpose of this study is to compare the therapeutic efficacy of intrauterine device and uterine artery embolization for uterine adenomyosis.

Screening

• History, Physical examination
• Laboratory test (Hemoglobin) / MRI
• Pictorial blood loss assessment chart
• Symptom/Quality of life score

Intervention

• Intrauterine device or uterine artery embolization
• Adverse event montoring

Follow-up visit #1 (1 month)

• Vital signs
• blood test (Hemoglobin) / Ultrasound
• Adverse event monitoring

Follow-up visit #2 (3 month)

• MRI only for embolization patients

Follow-up visit #3 (6 months)

• Blood test (Hemoglobin) / Ultrasound
• Pictorial blood loss assessment chart
• Symptom/Quality of life score

Follow-up visit #4 (12months)

• Blood test (Hemoglobin) / Ultrasound
• Pictorial blood loss assessment chart
• Symptom/Quality of life score

Inclusion Criteria:

1. Women with symptomatic fibroids (age: 19 - 48 years old) 2. Hemglobin < 12g/dL, 3. Symptoms of adenomysis (Menorrhagia, Dysmenorrhea)

Exclusion Criteria:

1. Gynecologic malignancy 2. Ongoing infection or inflammation 3. Coagulopathy (platelet < 50,000 or INR > 1.5) 4. Concomitant endometriosis 5. Pregnancy