A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (MIRANDA)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (MIRANDA)
The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab administered subcutaneously (SC) in adult participants with symptomatic COPD with a history of ≥ 2 moderate or ≥ 1 severe exacerbations of COPD in the 12 months prior to enrolment. Participants should be receiving optimised treatment with inhaled maintenance therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) throughout at least the last 3 months prior to enrolment.
Inclusion Criteria:
Exclusion Criteria:
CABA, C1025ABI, Argentina
CABA, C1425BEN, Argentina
Ciudad de Buenos Aires, C1414AIF, Argentina
Veliko Tanovo, 5000, Bulgaria
Chile, 7770484, Chile
Epagny Metz-Tessy, 74370, France
München-Pasing, 81241, Germany
Asahikawa-shi, 070-8644, Japan
Fujieda-shi, 426-8677, Japan
Ginowan-shi, 901-2214, Japan
Habikino-shi, 583-8588, Japan
Hakodate-shi, 041-8680, Japan
Itabashi-ku, 173-8610, Japan
Izumi-shi, 594-0073, Japan
Kusatsu-shi, 525-8585, Japan
Matsusaka-shi, 515-8544, Japan
Minokamo Shi, 505-8510, Japan
Mizunami-shi, 509-6134, Japan
Nankoku-shi, 783-8505, Japan
Nankoku-shi, 783-8509, Japan
Omuta-shi, 837-0911, Japan
Sagamihara-shi, 252-0143, Japan
Sagamihara-shi, 252-0315, Japan
Sakaide-shi, 762-8550, Japan
Tachikawa-shi, 190-8531, Japan
Toon-shi, 791-0281, Japan
Toshima-ku, 171-0014, Japan
Toyonaka-shi, 560-8552, Japan
Yanagawa-shi, 832-0059, Japan
Muang, 22000, Thailand
Muang, 40002, Thailand
Mueang, 20000, Thailand
Tarasove Village, 45634, Ukraine
Hochiminh, 70000, Vietnam