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The investigators planned this study to investigate the effects of dexmedetomidine administration on intraoperative hemodynamic stability in patients with pheochromocytoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexmedetomidine group | Experimental | In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery. |
|
| Control group | Active Comparator | In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dexmedetomidine | Drug | In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery. The research nurse, who did not participate in the study other than the management and preparation of the study medication, prepared 50mL of 0.9% normal saline for the control group and a mixture of dexmedetomidine 2 mL and 0.9% normal saline 48 mL (at a concentration of 4 μg/mL) for the dexmedetomidine group. |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative hemodynamic stability ( maximum blood pressure during surgery (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP)) | during operation | |
| Intraoperative hemodynamic stability (duration of SBP increase by 30% or more from baseline (in minutes) | during operation | |
| Intraoperative hemodynamic stability (duration of SBP exceeding 200 mmHg) | during operation | |
| Intraoperative hemodynamic stability (maximum HR during surgery) | during operation | |
| Intraoperative hemodynamic stability (duration of HR exceeding 110 beats per minute during surgery) | during operation | |
| Intraoperative hemodynamic stability (comparison of the quantity of vasoactive drugs (nitroprusside, esmolol, norepinephrine) used during surgery) | during operation |
| Measure | Description | Time Frame |
|---|---|---|
| levels of catecholamines | the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points | immediately after anesthesia induction |
| levels of catecholamines |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Young Jun Oh, M.D., Ph.D. | Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D010673 | Pheochromocytoma |
| ID | Term |
|---|---|
| D010235 | Paraganglioma |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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|
| 0.9% normal saline | Drug | In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation. |
|
the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points
| immediately after removal of the pheochromocytoma |
| levels of catecholamines | the actual secretion levels of catecholamines, specifically epinephrine and norepinephrine, were measured at different time points | immediately after the completion of surgery |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |