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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01AA030464-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| University of California, Berkeley | OTHER |
| Makerere University | OTHER |
| Infectious Diseases Research Collaboration, Uganda | OTHER |
| Kenya Medical Research Institute |
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This study will evaluate the effect of a brief alcohol counseling intervention on PrEP and PEP adherence among adults with heavy alcohol use at high risk for HIV, while gaining insights into the facilitators, barriers, and cost-effectiveness of this approach.
The investigators have developed a mobilization strategy of integrating HIV testing within multi-disease screening to recruit >2,000 people from drinking venues in Kenya and Uganda and invite them to begin biomedical HIV prevention if eligible (OPAL Aim 1; NCT05862857)
Following uptake of biomedical HIV prevention, persons with heavy alcohol use face challenges with retention in care and adherence to PrEP/PEP. The investigators have adapted a brief alcohol counseling intervention (Health Living Intervention) to reduce alcohol use and promote antiretroviral therapy (ART) adherence and HIV viral suppression among persons with HIV in Kenya and Uganda. The investigators now need to determine whether this intervention can promote retention in biomedical prevention and PrEP/PEP adherence among adults with heavy alcohol use.
Specific Aims:
The proposed research will address the critical intersection of alcohol use and HIV risk in SSA, by promoting retention of biomedical HIV prevention and exploring associated facilitators and barriers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard of Care (Control) | Active Comparator | Standard of care; alcohol counseling per Ministry of Health (MoH) guidelines |
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| Healthy Living Intervention | Experimental | Healthy Living Intervention in-person alcohol counseling with booster phone calls |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Healthy Living Intervention (HLI) | Behavioral | The Healthy Living Intervention (HLI) is a brief alcohol counseling intervention developed using the Information, Motivation, and Behavioral skills (IMB) model, a framework in which information, motivation, and behavioral skills are key determinants of health behavior. Participants initiating PrEP will be randomized to either HLI or standard of care alcohol counseling. |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of follow up time on biomedical prevention with PrEP or PEP | The proportion of time during the 24 weeks after PrEP/PEP initiation that a person is protected from HIV with PrEP/PEP, assessed by prescription refill data. Prescription refill data will be collected from MoH medical and pharmacy records, augmented by OPAL case report forms. | Measured 24 weeks after PrEP or PEP initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of follow up time on biomedical prevention with PrEP or PEP- 48 weeks | Secondary analysis of the primary outcome will measure the proportion of time that a person is protected from HIV with PrEP/PEP over 48 weeks, with integrated drug levels measured in hair samples collected at 48 weeks. | Measured over 48 weeks after PrEP or PEP initiation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kara Marson, MPH | Contact | 650-346-5774 | kara.marson@ucsf.edu | |
| Gabriel Chamie, MD, MPH | Contact | gabriel.chamie@ucsf.edu |
| Name | Affiliation | Role |
|---|---|---|
| Gabriel Chamie, MD, MPH | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kenya Medical Research Institute (KEMRI) | Recruiting | Mbita | Kenya |
Per the approved Data Sharing agreement with the NIAAA Data Archive, the investigators will share de-identified IPD from our baseline questionnaire, which includes questions about subject demographics, HIV risk, and alcohol use.
Data requests can be submitted starting 3 months after article publication and the data will be made accessible for up to 36 months. Extensions will be considered on a case-by-case basis.
Access to trial IPD can be requested by qualified researchers engaging in independent scientific research, and will be provided following review and approval of a research proposal and Statistical Analysis Plan (SAP).
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| D000428 | Alcohol Drinking |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D019984 | Quality Indicators, Health Care |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |
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| OTHER |
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
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| Standard of Care | Behavioral | Participants who are randomized to the control arm will receive basic alcohol counseling through the Ministry of Health if it is provided as standard of care. |
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| Proportion of participants with unhealthy alcohol use (defined by AUDIT-C ≥3 for women, ≥4 for men, and phosphatidylethanol (PEth) ≥50 ng/mL) at week 48 | Study staff will assess AUDIT-C scores (modified to refer to the prior 3 months, with a minimum of 0, indicating no alcohol use, and a maximum of 12) with a standard drink guide adapted to local context at baseline and every 12-weeks post-baseline. Blood will also be collected, and dried blood spots prepared for phosphatidylethanol (PEth) testing (measured in ng/mL with higher levels associated with greater alcohol use) at baseline and 48-weeks for confirmation of self-reported alcohol use. | Measured 48 weeks after PrEP or PEP initiation |
| Proportion of participants with HIV seroconversion by week 48 | HIV seroconversion will be measured as documented rapid HIV antibody test positivity with Geenius confirmation or documented detectable HIV viral load, with rapid HIV testing. HIV testing will occur at PrEP refill and injection visits, or completion of a course of PEP. | Measured 48 weeks after PrEP or PEP initiation |
| Infectious Diseases Research Collaboration (IDRC) | Recruiting | Mbarara | Uganda |
|
| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D004327 | Drinking Behavior |
| D001519 | Behavior |