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Vitiligo is a auto immune that impact 2% of the global population, regardless from the phototype. Even though it affects patients in a physical way through loss of pigmentation, it is also impacting them on a mental/emotional way.11-12 Current treatments offer a symptomatic solution to patients, however the response rate can be low and results can be slow.
Pediatric patients in vitiligo deserves special care as frequently (50%), the disease onset is before 20 years of age and, in 25% of the cases, it starts before the age of 10 years.13 Also, the current treatments for children are limited since it can involve pain and claustrophobia. The combination therapy of the study could offer a painless and easy treatment to follow.
If the combination of those two therapies can fasten and improve the response rate, this could be a good option to treat this condition not only in children, but also for adults patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tacrolimus + excimer light (group A) | Active Comparator | group A, will be treated by Tacrolimus 0.1% ointment twice daily and excimer light 308nm twice weekly (exciplex®) |
|
| Tacrolimus (group B) | Active Comparator | group B will start on Tacrolimus 0.1% ointment twice daily alone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exciplex | Device | exciplex, excimer lamp 308nm produced by clarteis |
|
| Measure | Description | Time Frame |
|---|---|---|
| repigmentation rate | Baseline, photos will be taken and the exact sites involved will be recorded. The clinical improvement measured by the percentage of repigmentation will be assessed and compared between the two mentioned groups at 1,2, 3 and 4 months. | 1,2,3 and 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King Abdullah University Hospital | Ar Ramtha | 21410 | Jordan |
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| Tacrolimus ointment | Drug | tacrolimus monohydrate ointment 0.1% TACRUS |
|
| ID | Term |
|---|---|
| D014820 | Vitiligo |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| D012871 | Skin Diseases |
| D001327 | Autoimmune Diseases |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D017437 | Skin and Connective Tissue Diseases |
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
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