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| ID | Type | Description | Link |
|---|---|---|---|
| IRAS ID: 328944 | Other Identifier | HRA |
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The goal of this observational study is to learn how accurately blood pressure can be measured using a contactless radar device.
The main questions the study aims to answer are:
Participants in this study will have the following tests:
Group 1: blood pressure measured with the radar device and a cuff when resting Group 2: blood pressure measured with the radar device and by placing a small tube inside the arteries of the wrist (during a clinical procedure) Group 3: blood pressure measured with the radar device and a cuff during a cardiac MRI scan Group 4: blood pressure measured with the radar device and a cuff during exercise
High blood pressure is the biggest risk factor for heart attacks and strokes. There are several machines available for measuring blood pressure, but most of them need to contact the skin causing discomfort from the inflatable cuff or risking the transmission of infections from reusing cuffs. There are also situations where the cuff machines are inaccurate, such as in older people or during exercise. Therefore, the investigators are trying to develop an accurate contactless system for measuring blood pressure.
The investigators have used advanced but safe radar to create a small machine with a camera that can measure blood pressure from a distance without the need to contact the participant's skin anywhere. It works by detecting tiny movements and changes on the skin produced from the heartbeat and pulse that cannot be seen with the human eye. The investigators want to study how accurate our radar blood pressure machine is by comparing it to other traditional methods of measuring blood pressure.
Firstly, radar blood pressure will be compared to auscultatory blood pressure (a blood pressure system using a cuff) in a group of 25 participants at rest attending a specialist blood pressure clinic. This is currently the internationally recommended method for validating new blood pressure devices.
Then radar blood pressure will be compared with invasive blood pressure (measured inside the arteries by a small tube) in 50 participants undergoing clinically-indicated cardiac catheterisation at the Royal Free Hospital.
Next a radar device capable of measuring blood pressure in participants lying inside the cardiovascular magnetic resonance (CMR) scanner will be developed. The radar blood pressure derived in the CMR scanner will be compared to oscillometric blood pressure in 25 participants (a cuff-based BP system that is currently used in patients being scanned). Finally, radar-BP will be compared with oscillometric BP in 50 participants during exercise including sit-to-stand movements and using a bike ergometer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Comparing radar and auscultatory blood pressure | 25 participants will be recruited from a specialist hypertension clinic. These participants will undergo the following tests:
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| Comparing radar and invasive blood pressure | Participants will be recruited from a list of patients scheduled to attend the Royal Free Hospital catheterisation laboratory for a clinically-indicated invasive angiogram that was booked by their consultant. 50 participants aged 18 and over will be recruited. The radar blood pressure measurements taken during the angiogram will not impact on the procedure or standard clinical care which the participant will receive. The duration of the visit is determined by the duration of the coronary angiogram and that is decided by the clinical care team. Participants will have the following tests:
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| Testing if the radar device can measure blood pressure in the MRI scanner | First we will develop a radar blood pressure device that can be used in the MRI scanner. When this device has been proven to be safe, we will recruit 25 participants to have the following tests:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Radar blood pressure device | Diagnostic Test | The radar blood pressure device will be compared with other traditional blood pressure measurement methods. |
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| Measure | Description | Time Frame |
|---|---|---|
| Radar blood pressure compared with blood pressure measured by manual auscultation | To determine if the radar module can derive accurate blood pressure measurements when compared against non-invasive blood pressure measurements by manual auscultation in a group of participants with known hypertension. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Radar blood pressure compared with blood pressure measured invasively | To compare the blood pressure measurements from the radar BP device with invasive blood pressure measurements obtained at the time of coronary angiography | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Radar blood pressure compared with oscillometric blood pressure during a cardiac MRI scan | To compare the radar BP measurements with readings from an oscillometric cuff during a cardiac MR scan | 3 years |
| Radar blood pressure compared with oscillometric blood pressure during exercise |
Inclusion Criteria:
Group 1:
Group 2:
Group 3:
Group 4:
- Age > 18
Exclusion Criteria:
Group 1
Group 2:
Group 3:
Group 4:
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Group 1: participants under the specialist hypertension clinic at the Royal Free Hospital Group 2: participants who have been selected to undergo an angiogram by a consultant cardiologist Group 3 and 4: healthy volunteers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Debbie Falconer, MBBS | Contact | 07984548291 | debbie.falconer@nhs.net | |
| Gabriella Captur, PhD | Contact | 02076705702 | gabriella.captur@ucl.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Gabriella Captur, PhD | University College, London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCL Bloomsbury Centre for Clinical Phenotyping | London | SW13 0JD | United Kingdom |
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25 participants will undergo radar blood pressure tests during an MRI scan of the heart. In these participants, a point of care blood test will be taken to assess kidney function using the StatSensor Xpress Creatinine monitor (Nova Biomedical, USA). Additional blood tests will also be collected for storage and future DNA and small molecule analysis.
The other participants will not have biospecimens stored.
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| Testing if the radar device can measure blood pressure during exercise | We will recruit 50 participants the have the following tests:
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To compare the radar BP measurements with readings from an oscillometric cuff during exercise. |
| 3 years |