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Tapia syndrome is a rare and poorly understood pathology. It is defined by a concomitant attack of the recurrent (branch of X) and hypoglossal (XII) nerves of peripheral or central origin. It is characterized by the paralysis of a vocal cord and the ipsilateral half of tongue. This damage is most often unilateral but it can also be bilateral. It results in dysphonia and swallowing disorders.
Tapia syndrome is a rare and poorly understood pathology. To date, less than 100 cases have been described in the literature. Previous works are mainly case reports and literature reviews. No prevalence study has been performed to date. Furthermore, disagreements persist regarding the semiology. Indeed, the involvement of the soft palate is not always described.
The main aim of this study was to determine the prevalence of Tapia syndrome in patients admitted to weaning unit after prolonged (>48h) orotracheal intubation in the ICU.
The secondary objectives are to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| "Non Tapia group" | Patients without Tapia's syndrome |
| |
| "Tapia group" | Patient with Tapia's syndrome |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diagnosis of Tapia's Syndrome | Diagnostic Test | The diagnostic includes :
|
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of Tapia's syndrome | The main objective of this study is to determine the prevalence of Tapia syndrome in patients admitted to the weaning unit after prolonged orotracheal intubation in intensive care. The orotracheal intubation is defined as an intubation longer than 48 hours. | through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Lingual involvment | yes/no/measure of lingual deviation in mm and width of each half of tongue in mm with MEEI software) | through study completion, an average of 2 years |
| Soft palate involvement |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who were intubated during more than 48 hours in ICU then tracheostomized and hospitalized in weaning unit.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Estelle ROBIN, SLT | Contact | 01.60.64.62.41 | erobin@cognacq-jay.fr | |
| Aymeric LE NEINDRE, Dr | Contact | 01.60.64.60.93 | aleneindre@cognacq-jay.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Forcilles | Recruiting | Férolles-Attilly | Seine-et-Marne | 77150 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22179851 | Background | Lykoudis EG, Seretis K. Tapia's syndrome: an unexpected but real complication of rhinoplasty: case report and literature review. Aesthetic Plast Surg. 2012 Jun;36(3):557-9. doi: 10.1007/s00266-011-9849-y. Epub 2011 Dec 17. | |
| 32088986 | Background | De Luca P, Cavaliere M, Scarpa A, Savignano L, Cassandro E, Cassandro C, Iemma M. Rehabilitation Protocol for Unilateral Laryngeal and Lingual Paralysis (Tapia Syndrome): Comment About "A Challenging Case of Tapia Syndrome After Total Thyroidectomy" By Ildem Deveci, Mehmet Surmeli, and Reyhan Surmeli. Ear Nose Throat J. 2021 Sep;100(5_suppl):734S-737S. doi: 10.1177/0145561320907433. Epub 2020 Feb 23. |
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yes/no
| through study completion, an average of 2 years |
| Determining the factors associated with Tapia syndrome | Determining the factors associated with Tapia syndrome : number of prone sessions, duration of intubation (day), duration of mechanical ventilation (day), tracheostomy duration (day), Cormack-Lehane's class, time to tracheostomy cannula removal (day), the time to resume oral feeding (day), number of days in the ICU, number of days in weaning unit, the number of pulmonary infections during the intubation and tracheostomy period, sex, the size of the intubation probe in mm | The day of inclusion |
| Dysphonia | GRBAS, maximum time of phonation (s), base frequency (Hz), jitter (%), harmonic noise ratio (dB), vocal range (dB), vocal tessitura (dB) | After initial swallowing test, maximum 1 week |
| Dysphagia | Functional oral intake scale (Level 1-Nothing by mouth to Level 7-Total oral diet with no restrictions) | through study completion, an average of 2 years |
| Nasofibroscopy | immobility of one or both vocal cords on nasofibroscopy | After initial swallowing test, maximum 1 week |
| Ultrasound | hyoid-mandibular distance at rest and during swallowing in cm), tongue thickness at rest in cm, geniohyoidien thickness in mm and area in mm2, echogenicity (Heckmatt score), vallecula stasis (yes/no), stasis in the piriform sinuses (yes/no) | After initial swallowing test, maximum 1 week |
| 20098201 | Background | Boga I, Aktas S. Treatment, classification, and review of Tapia syndrome. J Craniofac Surg. 2010 Jan;21(1):278-80. doi: 10.1097/SCS.0b013e3181c678f0. |
| 35410105 | Background | Caranti A, Bianchini C, Corazzi V, Pelucchi S, Ciorba A. Tapia's Syndrome: keep it in mind! Minerva Anestesiol. 2022 Apr;88(4):293-299. doi: 10.23736/S0375-9393.21.16037-7. |
| 32518147 | Background | Decavel P, Petit C, Tatu L. Tapia syndrome at the time of the COVID-19 pandemic: Lower cranial neuropathy following prolonged intubation. Neurology. 2020 Aug 18;95(7):312-313. doi: 10.1212/WNL.0000000000010011. Epub 2020 Jun 9. No abstract available. |