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| Name | Class |
|---|---|
| American Heart Association | OTHER |
| Schaeffer Center for Health Policy & Economics | UNKNOWN |
| Alzheimer's Therapeutic Research Institute | OTHER |
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This single-blind, three-arm, randomized, controlled trial will assess the impact of messages and financial incentives on the enrollment of demographically diverse individuals to the Alzheimer Prevention Trials (APT) Webstudy. The APT Webstudy is a novel, online registry that employs quarterly cognitive testing using validated platforms. The APT Webstudy implements fully remote assessments, coordinated by the Alzheimer's Therapeutic Research Institute (ATRI) under USC IRB #HS-17-00746. The purpose of the current study is to test whether we can increase enrollment of diverse individuals into the registry. To do this, we will work with Contra Costa Regional Medical Center (CCRMC), the county public hospital and its affiliated health centers in Contra Costa County, California, to test whether sending messages with and without financial incentives to patients who receive primary care with the health system can increase enrollment to the APT Webstudy. The investigators hypothesize that 1) a certain small financial incentive and an award opportunity based incentive (or a drawing with a prize) will increase enrollment rates of CCHS members into the APT Webstudy relative to the control group. The investigators further hypothesize that the award opportunity incentive will increase the enrollment rate of CCRMC patients into the APT Webstudy more than a certain financial incentive with the same expected value.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Messaging Only | Active Comparator | 16,000 participants will be randomized to Arm 1 where no monetary incentive is offered. |
|
| Small Incentive | Experimental | 16,000 participants will be randomized to Arm 2 where a small one-time monetary incentive is offered. |
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| Prize Incentive | Experimental | 16,000 participants will be randomized to Arm 3 where an opportunity based incentive (or a drawing with a prize) with a single winner will be offered. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Financial Incentives | Behavioral | Small financial incentive or prize incentive |
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| Measure | Description | Time Frame |
|---|---|---|
| Enrollment status into the APT Webstudy | APT Webstudy enrollment rate based on completion of at least one of the two APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery). | 2-weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cost per enrollee | Cost to acquire an enrollment | annual |
| Completion of cognitive assessments within the APT Webstudy | Completion of both APT Webstudy cognitive assessments (Cognitive Function Instrument [CFI] and/or Cogstate Brief Battery). |
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Inclusion Criteria:
To be eligible to participate in this study, an individual must meet all of the following criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Contra Costa Health Plan | Martinez | California | 94553 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40844772 | Derived | Jacobson M, Molina-Henry D, Chang TY, Jimenez-Maggiora GA, Pramanik R, Shah SB, Aisen PS. Financial Incentives to Increase Diversity of Older Participants in a Memory Concerns Registry: A Randomized Clinical Trial. JAMA Health Forum. 2025 Aug 1;6(8):e252273. doi: 10.1001/jamahealthforum.2025.2273. |
| Label | URL |
|---|---|
| APT Webstudy | View source |
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The health system will not allow sharing of individual data on a public site. However, we will share data on request from investigators.
Data will be made available within 6 months of publication.
Individual data shared upon request.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Sep 6, 2023 | Sep 7, 2023 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
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| Message | Behavioral | Message inviting participant to enroll |
|
| 2-weeks |
| D019636 |
| Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |