Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer

Application of Serum Bile Acid Profile in the Diagnosis of Gastric Cancer

In this study, the composition and level of serum bile acids in patients with gastric cancer and non-gastric cancer were analyzed by detecting the serum bile acid profile, so as to develop new serological diagnostic methods for early diagnosis and treatment of gastric cancer.

Inclusion Criteria:

1. Age between 18-70, both gender;
2. The gastric cancer group was early gastric cancer or advanced gastric cancer diagnosed by endoscopic examination and pathological biopsy. The non-gastric cancer group included patients without gastric lesions, superficial gastritis, chronic atrophic gastritis, intestinal metaplasia or dysplasia diagnosed by gastroscopy or pathological biopsy;
3. Informed consent was obtained.

Exclusion Criteria:

1. The patients have diseases that affect bile acid metabolism, such as liver cirrhosis, gallstones or inflammatory bowel disease, Behcet's disease, etc;
2. Due to other diseases, the patient took drugs affecting bile acid metabolism, such as cholestyramine, anti-inflammatory Lidan tablets, Danshu capsules, ursodeoxycholic acid, obticholic acid, Schisandrin B, tanshinone ⅡA, Yinzhihuang, etc;
3. Pregnant women;
4. Primary tumors of other systems were diagnosed;
5. Those with poor physiopathological conditions, such as chronic kidney disease requiring long-term dialysis;
6. Patients with mental illness;
7. Patients who have received radiotherapy or surgery previously;
8. Those with poor adherence or difficult to follow up.