sIRB determined feasibility study could not be done because of no benefits of the treatment drops in short time violated FDA requirements

Participants eligible for the study will be randomized to one of three concentrations of atropine and followed for a month.

Participants will be identified through screening that fit the criteria of a pre-myopic child, which will depend on age and the amount of refractive error at that time. These children will be randomized for a pilot study measuring compliance in nightly eye drop administration. The outcome will be thirty days after randomization, and will assess whether or not there is a difference in compliance between one of three dosages of atropine (0.01%, 0.03%, and 0.05%).

Inclusion Criteria:

• Age: 6-11 years

• Refractive error measured in spherical equivalent, one eye meets criterion

  • 6 years old: 0.50 to +0.38
  • 7 years old: 0.50 to +0.25
  • 8-11 years old: 0.50 to plano

• Anisometropia: spherical equivalent <1.50 D

• Astigmatism: <1.50 in both eyes

• Myopia: Less myopic than -0.74 D, both eyes

Exclusion Criteria:

● Myopic

De-identified bottles will be sent to the sites with randomization codes. The key will be kept at the data coordinating center.