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Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies. Bronchial asthma is associated with bronchial asthma in 40% of patients with AR, suggesting a comorbid feature of allergic disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Interleukin-4 receptor responders 1 | Experimental | Recombinant fully human anti-IL4Rα monoclonal antibody drug. |
|
| Interleukin-4 receptor responders 2 | Experimental | Recombinant fully human anti-IL4Rα monoclonal antibody drug. |
|
| Placebo | Placebo Comparator | Recombinant fully human anti-IL4Rα monoclonal antibody drug. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GR1802 injection-1 | Biological | subcutaneous,dose*1 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Average change from baseline in daily retrospective total nasal symptom score (rTNSS) during treatment period. | The Total Nasal Symptom Score (TNSS) is the sum of the four symptom scores of runny nose, nasal congestion, nasal itching, and sneezing, with each symptom scoring from 0 to 3. | week 4 |
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Key Inclusion Criteria:
Key Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zheng Liu, PHD | Contact | 027-83665555 | zhengliuent@hotmail.com | |
| Rong fei Zhu, PHD | Contact | 027-83665555 | zrf13092@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji Hosptial affiliated to Tongji Medical college of Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430030 | China |
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| ID | Term |
|---|---|
| D065631 | Rhinitis, Allergic |
| ID | Term |
|---|---|
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
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| GR1802 injection-2 | Biological | subcutaneous,dose*2 |
|
|
| Placebo | Biological | subcutaneous,dose*2 |
|
| D010038 |
| Otorhinolaryngologic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |