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| Name | Class |
|---|---|
| National Pork Board | OTHER |
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We will be directly comparing a high-quality protein diet composed primarily of lean pork loin (PORK) to a lower-quality plant-based protein diet (PLANT) in individuals with prediabetes on muscle and whole-body protein turnover and glucose regulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Quality Protein Intake - Lean Pork | Active Comparator | Meal patterns will mimic a standard American diet (50% carbohydrate, 15% protein, 35% fat), providing an isonitrogenous 0.8 g/kg/d protein, and meeting individual estimated daily energy requirements. We have chosen 0.8 g/kg/d as it is the recommend dietary allowance for protein in the US. This arm's protein source will be from lean pork. |
|
| Low Quality Protein Intake - Plant-Based | Active Comparator | Meal patterns will mimic a standard American diet (50% carbohydrate, 15% protein, 35% fat), providing an isonitrogenous 0.8 g/kg/d protein, and meeting individual estimated daily energy requirements. We have chosen 0.8 g/kg/d as it is the recommend dietary allowance for protein in the US. This arm's protein source will be from plant-based protein (ie impossible burger, black bean burger, soy, etc). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lean Pork vs Plant-Based Protein | Other | Participants will eat prepared study meals for three days that have either protein sourced from lean pork or plant-based sources. |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle Protein Synthesis | Mixed muscle protein synthesis expressed as the fractional synthetic rate. | 24 hours |
| Whole Body Protein Balance | Amount of net protein gained per unit of time. | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Whole Body Protein Synthesis | Amount of protein produced per unit of time. | 24 hours |
| 24-hour Mean Glucose | Derived from continous glucose monitor data. |
| Measure | Description | Time Frame |
|---|---|---|
| Whole Body Protein Breakdown | Amount of protein broken down per unit of time. | 24 hours |
| Whole Body Protein Flux | Amount of protein turnover per unit of time. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| David Church, PhD | Contact | 501-526-5769 | dchurch@uams.edu | |
| Amanda Gwin, PA-C | Contact | 5018380096 | algwin@uams.edu |
| Name | Affiliation | Role |
|---|---|---|
| David Church, PhD | University of Arkansas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Recruiting | Little Rock | Arkansas | 72205 | United States |
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| ID | Term |
|---|---|
| D006943 | Hyperglycemia |
| D011236 | Prediabetic State |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D003920 | Diabetes Mellitus |
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| 24 hours |
| 24 hours |
| Glucose Regulation and Homeostasis | Derived from continuous glucose monitor data. | 24 hours |
| D004700 | Endocrine System Diseases |