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Spectral CT is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. It uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. The dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.
First of all, the virtual creation of mono-energy images between 40 and 140 keV has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40keV). It has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. However, its performance in oncology analysis has been little studied. The selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate.
Spectral CT provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional CT acquisition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Colo-rectal Cancer | Patients with Colo-rectal Cancer will be included. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CT Images | Other | Analysis of CT images of peritoneal and/or liver metastases from colorectal cancer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of peritoneal lesion mapping between spectral scanning and conventional scanning | Comparison of peritoneal lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition). | Year : 1 |
| Comparison of hepatic lesion mapping between spectral scanning and conventional scanning | Comparison of hepatic lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition). | Year : 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of response to chemotherapy in RECIST 1.1 | Collection of demographic, biological and surgical data. | Year : 1 |
| Evaluation of response to chemotherapy in Radiomics | Collection of demographic, biological and surgical data. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with synchronous or metachronous peritoneal and/or liver metastases of colorectal cancer with curative surgical plans.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rémi GRANGE, MD | Contact | (0)477828963 | +33 | remi.grange@chu-st-etienne.fr |
| Sylvain GRANGE, MD | Contact | (0)477829066 | +33 | sylvain.grange@chu-st-etienne.fr |
| Name | Affiliation | Role |
|---|---|---|
| Rémi GRANGE, MD | Centre Hospitalier Universitaire de Saint Etienne | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Saint-Etienne | Recruiting | Saint-Etienne | 42000 | France |
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| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
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| Year : 1 |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |