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The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)
The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| JIA cases | juvenile idiopathic arthritis cases |
| |
| CONTROL | age and sex matched healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR) | Diagnostic Test | measurement of serum albumin, fibrinogen and CRP |
|
| Measure | Description | Time Frame |
|---|---|---|
| The fibrinogen to albumin ratio | measurement of serum fibrinogen and albumin | 3 months |
| The CRP to albumin ratio | measurement of serum CRP and albumin | 3 MONTHS |
| Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side | correlation of these ratios with JADAS27 | 3 MONTHS |
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Inclusion Criteria:
Exclusion Criteria:
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All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects.
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| ID | Term |
|---|---|
| D001171 | Arthritis, Juvenile |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |