Administrative burden

The goal of this clinical trial is to compare a sterile vapocoolant spray to EMLA cream in children with access ports.

Participants will receive either the spray or cream prior to port access and rate pain on a scale.

Researchers will compare spray vs cream to see if the spray is as effective as the cream in reducing pain associated with port puncture.

Inclusion Criteria:

• English-speaking
• Present appointment is for drawing blood, receiving intravenous antibiotics, blood products, or chemotherapy
• EMLA cream has (standard of care) or has not (vapocoolant) been applied to the port site prior to the appointment
• Previous allergic reaction or skin irritation due to EMLA
• Quick access to the child's port is needed for drawing blood, or giving treatments, blood products, or drugs such as chemotherapy

Exclusion Criteria:

• Child has a legal guardian or non-parent family member as the only adult with them for the visit.
• Children less than 4 years of age
• Children with altered mental status
• History of traumatic brain injury, developmental delay or autism
• Child is nonverbal
• Present appointment is for drawing blood, receiving intravenous antibiotics, blood products, or chemotherapy, and child and parents prefer to wait for EMLA cream to take effect.