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The goal of this retrospective observational study is to compare brain fluorodeoxyglucose-positron emission tomography (FDG-PET) of patients with autoimmune encephalitis, normal controls and patients with Alzheimer's disease (AD). The main question it aims to answer is:
•is there a specific pattern of brain metabolism in patients with autoimmune encephalitis Participants data and images will be retrospectively collected from hospital records, and FDG-PET images will be analyzed by means of statistical parametric mapping (SPM). Controls will be selected from validated public databases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autoimmune Encephalitis patients | Patients with autoimmune encephalitis admitted to the centers, who underwent a brain FDG-PET during the course of their disease trajectory. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FDG-PET | Diagnostic Test | Brain FDG-PET |
|
| Measure | Description | Time Frame |
|---|---|---|
| SPM analysis of brain metabolic pattern | Pattern of brain metabolism in patients with autoimmune encephalitis compared with healthy controls and patients with Alzheimer's disease, drawn from validated published databases | up to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity of basal ganglia hypermetabolism | Sensitivity of basal ganglia hypermetabolism for the diagnosis of autoimmune encephalitis | up to 6 months |
| Diagnostic delay | Comparison of diagnostic delay with and without FDG-PET |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with autoimmune encephalitis admitted to the recruiting centers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Simone Beretta, MD, PhD | Contact | +390392333568 | simone.beretta@unimib.it | |
| Federico Emanuele Pozzi, MD | Contact | federicoemanuele.pozzi@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Simone Beretta, MD, PhD | University of Milano Bicocca | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Sanitaria Universitaria Friuli Centrale | Not yet recruiting | Udine | Friuli Venezia Giulia | Italy |
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| ID | Term |
|---|---|
| D020274 | Autoimmune Diseases of the Nervous System |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| up to 6 months |
| IRCCS Ospedale Policlinico San Martino | Not yet recruiting | Genoa | Liguria | Italy |
|
| Fondazione IRCCS Mondino | Recruiting | Pavia | Lombardy | Italy |
|
| Fondazione IRCCS Istituto Neurologico "Carlo Besta" | Not yet recruiting | Milan | Milano | 20133 | Italy |
|
| Ospedale San Paolo | Not yet recruiting | Milan | Milano | 20142 | Italy |
|
| Fondazione IRCCS San Gerardo dei Tintori | Recruiting | Monza | Monza e Della Brianza | 20900 | Italy |
|