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This study employed secondary database analysis of the Adelphi Dry Eye Disease (DED) Disease Specific Programmeā¢ (DSPā¢), a templatized cross-sectional survey with retrospective data collection that is administered by Adelphi to a convenience sample of patients diagnosed with DED, and their consulting physicians in the United States. In addition to the survey data, the DED DSP also included recorded medical history data as reported by physicians (optometrists, ophthalmologists or refractive surgeons).
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| Measure | Description | Time Frame |
|---|---|---|
| Impact of Dry Eye on Everyday Life questionnaireĀ© (IDEEL) mean scores | Mean IDEEL score on Symptom Bother dimension: score range 0-100, where higher scores indicate greater bother. Mean IDEEL scores on Daily Activities, Emotional Impact, and Work dimensions: score range 0-100, where higher scores indicate lesser impact. | Up to approximately 18 months |
| Work Productivity and Activity ImpairmentĀ© (WPAI) mean scores | A higher score on the WPAI indicates greater impairment and loss of productivity. | Up to approximately 18 months |
| Frequency of consultations | Up to approximately 18 months | |
| Frequency of DED-related hospitalizations | Up to approximately 18 months | |
| Number of emergency room (ER)/intensive care unit (ICU) admittances | Up to approximately 18 months | |
| Duration of ER/ICU admittances | Up to approximately 18 months | |
| Number of evaluations/tests administered | Up to approximately 18 months | |
| Frequency of evaluations/tests administered | Up to approximately 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with reasons for consultation, per category | Up to approximately 18 months | |
| Number of patients with current (at time of data capture) treatment regimen (prescribed, over-the-counter [OTC] treatments) | Up to approximately 18 months |
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Inclusion Criteria:
Main Sample:
XiidraĀ® Oversample:
Exclusion Criteria:
Main Sample:
ā¢ Involved in a DED clinical trial (at time of data collection).
XiidraĀ® Oversample:
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This was a retrospective, noninterventional cohort study
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| Name | Affiliation | Role |
|---|---|---|
| Novartis Pharmaceuticals | Novartis Pharmaceuticals | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Novartis | East Hanover | New Jersey | 07936 | United States |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| Number of patients with reasons for not currently receiving any treatment for patient's DED (where appropriate), per category | Up to approximately 18 months |
| Number of patients with reasons for switching away from previous treatment line (where appropriate), per category | Up to approximately 18 months |
| Number of patients with "other than cure their DED, the most important benefit a drug treatment could provide," per category | Up to approximately 18 months |
| Impact of Dry Eye on Everyday Life Treatment Satisfaction moduleĀ© (IDEEL-TSĀ©) mean score | Score range 0-100, where a higher score indicates greater satisfaction. | Up to approximately 18 months |
| Number of physicians assessing reasons for choice of current treatment line, per category | Up to approximately 18 months |
| Number of physicians assessing areas of improvement for current treatment line, per category | Up to approximately 18 months |
| Number of patients for whom cost/reimbursement was a driving factor in selection of current treatment | Up to approximately 18 months |
| Number of patients who were adherent to their current treatment plan, per category, as assessed by the physician | Up to approximately 18 months |
| Number of patients who were compliant to their current treatment plan, per category, as assessed by the physician | Up to approximately 18 months |
| Number of physicians assessing attributes associated with ideal medication, per category | Up to approximately 18 months |
| Number of physicians assessing attributes associated with currently prescribed medication, per category | Up to approximately 18 months |
| Number of physicians assessing influences on treatment decisions, per category | Up to approximately 18 months |