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This is a single-center, prospective diagnostic-accuracy study. All women who will undergo surgery for DE after preoperative ultrasound for six consecutive months will be included. Anamnestic and preoperative (physical objective and ultrasonographic) data of these patients will be collected. Surgical and pathological data will be analyzed to confirm the presence of parametrial DE.
This is a single-center, prospective diagnostic-accuracy study. All women who will undergo surgery for DE after preoperative ultrasound for six consecutive months will be included. Anamnestic and preoperative (physical objective and ultrasonographic) data of these patients will be collected. Surgical and pathological data will be analyzed to confirm the presence of parametrial DE.
All the study procedures are done according to our clinical practice. Demographic and ultrasonographic data will be collected from the preoperative evaluation, which is routinely done at our institution by four ultrasonographic expert in diagnosing deep endometriosis. Surgical and pathological data will be collected during surgical procedures and hospital stay.
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| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic accuracy | Diagnostic accuracy of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| Sensitivity | Sensitivity of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| Specificity | Specificity of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| positive predictive value | of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| negative predictive value | of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| Positive likelihood ratio | Positive likelihood ratio of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
| Measure | Description | Time Frame |
|---|---|---|
| Characteristics of parametrial DE | Characteristics of parametrial DE (parametrial localizations, size, margins, echogenicity) evaluated at preoperative ultrasound | Preoperative exam |
| Parametrial DE in the three different parametrial areas (posterior, lateral, and anterior parametrium) |
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Inclusion Criteria:
Exclusion Criteria:
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All women who will undergo surgery for DE after preoperative ultrasound for six consecutive months will be included.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Sacro Cuore Don Calabria di Negrar | Recruiting | Negrar | Verona | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38382700 | Derived | Barra F, Zorzi C, Albanese M, De Mitri P, Stepniewska A, Roviglione G, Giani M, Albertini G, Ferrero S, Ceccaroni M. Ultrasonographic characterization of parametrial endometriosis: a prospective study. Fertil Steril. 2024 Jul;122(1):150-161. doi: 10.1016/j.fertnstert.2024.02.031. Epub 2024 Feb 19. |
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| ID | Term |
|---|---|
| D004715 | Endometriosis |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| Negative likelihood ratio | Negative likelihood ratio of transvaginal ultrasound for detecting the intraoperative presence of parametrial DE with surgical and/or histological confirmation. | Preoperative exam, surgical and/or histological confirmation |
Diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of transvaginal ultrasound for distinguishing the intraoperative presence of parametrial DE in the three different parametrial areas (posterior, lateral, and anterior parametrium) with surgical and/or histological confirmation. |
| Preoperative exam, surgical and/or histological confirmation |
| Infiltration of parametrial DE nodules | Diagnostic accuracy, sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of transvaginal ultrasound for detecting the intraoperative infiltration of parametrial DE nodules in other pelvic structures (i.e. rectosigmoid, uterosacral ligaments) with surgical and/or histological confirmation | Preoperative exam, surgical and/or histological confirmation |
| Other DE nodules and indirect DE signs | Prevalence of other DE nodules and indirect DE signs in patients in the case of evidence of parametrial DE at preoperative ultrasound | Preoperative exam |
| D000091662 | Genital Diseases |