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The diagnosis of depressed left ventricular ejection fraction (dLVEF) (EF<50%) depends on golden standard ultrasound cardiography (UCG). A wearable synchronized phonocardiography (PCG) and electrocardiogram (ECG) device can assist in the diagnosis of dLVEF, which can both expedite access to life-saving therapies and reduce the need for costly testing.
The synchronized PCG and ECG is wirelessly paired with the WenXin Mobile application, allowing for simultaneous recording and visualization of PCG and ECG. These features uniquely enable this device to accumulate large sets of acoustic data on patients both with and without heart failure(HF).
This study is a Case-control study. In this study, the investigators seek to develop an artificial intelligence (AI) analysis system to identify dLVEF (EF<50%) by PCG and ECG. All adults (aged ≥18 years) planned for UCG were eligible to participate (inpatients and outpatients). Specifically, the investigators will attempt to develop machine learning algorithms to learn synchronized PCG and ECG of patients with dLVEF. Then we use these algorithms to identify dLVEF subjects. The investigators anticipate to demonstrate the wearable cardiac patch with synchronized PCG and ECG can reliably and accurately diagnose dLVEF in the primary care setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Model training group | Compare the results of PCG and ECG with UCG, and conduct model training analysis | ||
| Model validation group | Compare the results of PCG and ECG with UCG, and conduct model validation analysis |
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| Measure | Description | Time Frame |
|---|---|---|
| Determination of Heart Failure Disease | Heart Failure Disease was determined by EMAT (millisecond, ms)calculate from synchronized PCG and ECG signals using an artificial intelligence (AI) guided model. | one time assessment at baseline (approx. 5 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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This is one-center cohort study. Patients undergo echocardiogram at Ruijin Hospital.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenli Zhang, MD | Contact | +86 21 13917615339 | zwl11929@rjh.com.cn | |
| Bei Song, MD | Contact | +86 21 15821960139 | belasong@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Ruiyan Zhang, MD, PhD | Ruijin Hospital, Shanghai Jiaotong School of Medicine | Principal Investigator |
| Wenli Zhang, MD | Ruijin Hospital, Shanghai Jiaotong School of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ruijin Hospital, Shanghai Jiaotong School of Medicine | Recruiting | Shanghai | 200025 | China |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Bei Song, MD |
| Ruijin Hospital, Shanghai Jiaotong School of Medicine |
| Study Chair |
| Shanghai Chest Hospital, Shanghai Jiao Tong University School Of Medicine | Recruiting | Shanghai | 200030 | China |
|
| Shanghai East Hospital | Recruiting | Shanghai | 200123 | China |
|