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Cortisol is an essential for life hormone secreted in a pulsatile pattern on a diurnal rhythm. Given the complexity of cortisol secretion on a circadian rhythm with pulsations, current methods of cortisol measurement have limitations.
Therefore, a non-invasive and ambulatory method would be useful to measure cortisol levels in real-time.
The main aim of the study is to compare cortisol levels across biological fluids (sweat, saliva, interstitial fluid, and blood) in order to validate in the long term a continuous and non-invasive cortisol measurement device (currently under development).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 24 hours sampling of 4 biological fluids (blood, ISF, sweat and saliva) | Other | 24 hours sampling of 4 biological fluids:
|
| Measure | Description | Time Frame |
|---|---|---|
| Cortisol levels in 4 biologicals fluids | Comparison of cortisol levels in these 4 biological fluids | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Aldosterone levels in 4 biological fluids | Comparison of aldosterone levels in these 4 biological fluids | 24 hours |
| Glucocorticoid - comparison of repeated measures of glucocorticoid concentrations (cortisol, 18OHF, cortisone) profiles - over a period of 24 hours |
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Healthy controls:
Inclusion Criteria:
Exclusion Criteria:
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Healthy volunteers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adelina Ameti | Contact | 0041795568630 | adelina.ameti@chuv.ch | |
| Nathalie Vionnet, MD-PhD | Contact | nathalie.vionnet@chuv.ch |
| Name | Affiliation | Role |
|---|---|---|
| Nelly Pitteloud, MD | Centre Hospitalier Universitaire Vaudois | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire Vaudois (CHUV) | Recruiting | Lausanne | Canton of Vaud | 1005 | Switzerland |
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|
| 24 hours sampling of ISF or sweat (after validating the correlation with blood) | Other | 24 hours sampling in an ambulatory setting |
|
Study of the diurnal rhythm and pulsatility in healthy participants (and later patients)
|
| 24 hours |
| Mineralocorticoid - comparison of repeated measures of aldosterone concentrations profiles - over a period of 24 hours | Study of the diurnal rhythm and pulsatility in healthy participants (and later patients)
| 24 hours |
| ID | Term |
|---|---|
| D000309 | Adrenal Insufficiency |
| D003480 | Cushing Syndrome |
| D006929 | Hyperaldosteronism |
| ID | Term |
|---|---|
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
| D000308 | Adrenocortical Hyperfunction |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D013546 | Sweating |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D001833 | Body Temperature Regulation |
| D001831 | Body Temperature |
| D010829 | Physiological Phenomena |
| D006706 | Homeostasis |
| D012879 | Skin Physiological Phenomena |
| D055827 | Integumentary System Physiological Phenomena |
| D000222 | Adaptation, Physiological |
| D000220 | Adaptation, Biological |
| D001686 | Biological Phenomena |
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